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Thrombocytopenia according to antiretroviral drug combinations, viremia and CD4 lymphocytes among HIV-infected patients in Cameroon: a snapshot from the City of Yaoundé

OBJECTIVE: Thrombocytopenia is an abnormal decrease in blood platelets, which can affect the prognosis of people living with HIV (PLHIV). In order to assess the burden of this haematological disorder, we evaluated the frequency of thrombocytopenia according to antiretroviral drug combinations, virem...

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Autores principales: Nka, Alex Durand, Sosso, Samuel Martin, Fokam, Joseph, Bouba, Yagai, Teto, Georges, Simo Rachel, Rachel, Tiga, Aline, Yimga, Junie, Nukenine, Elias Nchiwan, Nanfack, Aubin Joseph, Takou, Désiré, Aroga, Zélateur, Colizzi, Vittorio, Ndjolo, Alexis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761711/
https://www.ncbi.nlm.nih.gov/pubmed/31554515
http://dx.doi.org/10.1186/s13104-019-4664-7
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author Nka, Alex Durand
Sosso, Samuel Martin
Fokam, Joseph
Bouba, Yagai
Teto, Georges
Simo Rachel, Rachel
Tiga, Aline
Yimga, Junie
Nukenine, Elias Nchiwan
Nanfack, Aubin Joseph
Takou, Désiré
Aroga, Zélateur
Colizzi, Vittorio
Ndjolo, Alexis
author_facet Nka, Alex Durand
Sosso, Samuel Martin
Fokam, Joseph
Bouba, Yagai
Teto, Georges
Simo Rachel, Rachel
Tiga, Aline
Yimga, Junie
Nukenine, Elias Nchiwan
Nanfack, Aubin Joseph
Takou, Désiré
Aroga, Zélateur
Colizzi, Vittorio
Ndjolo, Alexis
author_sort Nka, Alex Durand
collection PubMed
description OBJECTIVE: Thrombocytopenia is an abnormal decrease in blood platelets, which can affect the prognosis of people living with HIV (PLHIV). In order to assess the burden of this haematological disorder, we evaluated the frequency of thrombocytopenia according to antiretroviral drug combinations, viremia and the immune status of PLHIV. RESULTS: A cross-sectional and analytical study was conducted from June to November 2016 among 310 PLHIV at the “Chantal BIYA” International Reference Centre, Yaoundé, Cameroon. Overall rate of thrombocytopenia was 19.0% (59/310). The rate of thrombocytopenia was 64.6% (42/65) versus 6.9% (17/245) in ART-naïve versus ART-treated patients respectively, p < 0.0001. Following viral load, rate of thrombocytopenia was 15.8% (20/130) in those with undetectable viral load, and 34.1% (27/79) with viral loads > 3 log(10) RNA/ml (p = 0.03). As concerns CD4-count, rate of thrombocytopenia was 16.2% (42/259) in those with ≥ 200 CD4/mm(3) versus 33.3% (17/51) with < 200 CD4/mm(3) (p = 0.0003). After adjusting for sex, ART, viral load and CD4, Viral load and ART exposure were significantly associated with decreased risk of thrombocytopenia (p < 0.05). Thrombocytopenia occurs especially among ART-naïve, high viremia and severe immune-compromised patients. Interestingly, ART coverage appears as an independent factor in preventing the occurrence of thrombocytopenia.
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spelling pubmed-67617112019-09-30 Thrombocytopenia according to antiretroviral drug combinations, viremia and CD4 lymphocytes among HIV-infected patients in Cameroon: a snapshot from the City of Yaoundé Nka, Alex Durand Sosso, Samuel Martin Fokam, Joseph Bouba, Yagai Teto, Georges Simo Rachel, Rachel Tiga, Aline Yimga, Junie Nukenine, Elias Nchiwan Nanfack, Aubin Joseph Takou, Désiré Aroga, Zélateur Colizzi, Vittorio Ndjolo, Alexis BMC Res Notes Research Note OBJECTIVE: Thrombocytopenia is an abnormal decrease in blood platelets, which can affect the prognosis of people living with HIV (PLHIV). In order to assess the burden of this haematological disorder, we evaluated the frequency of thrombocytopenia according to antiretroviral drug combinations, viremia and the immune status of PLHIV. RESULTS: A cross-sectional and analytical study was conducted from June to November 2016 among 310 PLHIV at the “Chantal BIYA” International Reference Centre, Yaoundé, Cameroon. Overall rate of thrombocytopenia was 19.0% (59/310). The rate of thrombocytopenia was 64.6% (42/65) versus 6.9% (17/245) in ART-naïve versus ART-treated patients respectively, p < 0.0001. Following viral load, rate of thrombocytopenia was 15.8% (20/130) in those with undetectable viral load, and 34.1% (27/79) with viral loads > 3 log(10) RNA/ml (p = 0.03). As concerns CD4-count, rate of thrombocytopenia was 16.2% (42/259) in those with ≥ 200 CD4/mm(3) versus 33.3% (17/51) with < 200 CD4/mm(3) (p = 0.0003). After adjusting for sex, ART, viral load and CD4, Viral load and ART exposure were significantly associated with decreased risk of thrombocytopenia (p < 0.05). Thrombocytopenia occurs especially among ART-naïve, high viremia and severe immune-compromised patients. Interestingly, ART coverage appears as an independent factor in preventing the occurrence of thrombocytopenia. BioMed Central 2019-09-26 /pmc/articles/PMC6761711/ /pubmed/31554515 http://dx.doi.org/10.1186/s13104-019-4664-7 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Note
Nka, Alex Durand
Sosso, Samuel Martin
Fokam, Joseph
Bouba, Yagai
Teto, Georges
Simo Rachel, Rachel
Tiga, Aline
Yimga, Junie
Nukenine, Elias Nchiwan
Nanfack, Aubin Joseph
Takou, Désiré
Aroga, Zélateur
Colizzi, Vittorio
Ndjolo, Alexis
Thrombocytopenia according to antiretroviral drug combinations, viremia and CD4 lymphocytes among HIV-infected patients in Cameroon: a snapshot from the City of Yaoundé
title Thrombocytopenia according to antiretroviral drug combinations, viremia and CD4 lymphocytes among HIV-infected patients in Cameroon: a snapshot from the City of Yaoundé
title_full Thrombocytopenia according to antiretroviral drug combinations, viremia and CD4 lymphocytes among HIV-infected patients in Cameroon: a snapshot from the City of Yaoundé
title_fullStr Thrombocytopenia according to antiretroviral drug combinations, viremia and CD4 lymphocytes among HIV-infected patients in Cameroon: a snapshot from the City of Yaoundé
title_full_unstemmed Thrombocytopenia according to antiretroviral drug combinations, viremia and CD4 lymphocytes among HIV-infected patients in Cameroon: a snapshot from the City of Yaoundé
title_short Thrombocytopenia according to antiretroviral drug combinations, viremia and CD4 lymphocytes among HIV-infected patients in Cameroon: a snapshot from the City of Yaoundé
title_sort thrombocytopenia according to antiretroviral drug combinations, viremia and cd4 lymphocytes among hiv-infected patients in cameroon: a snapshot from the city of yaoundé
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761711/
https://www.ncbi.nlm.nih.gov/pubmed/31554515
http://dx.doi.org/10.1186/s13104-019-4664-7
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