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Disturbances of the Stress Response: The Role of the HPA Axis During Alcohol Withdrawal and Abstinence
Interactions among the brain, the pituitary gland, and the adrenal glands (i.e., the hypothalamic-pituitary-adrenal [HPA] axis) help regulate the body’s response to stress. The adrenal hormone cortisol plays a key role in stress reduction through its effects on multiple body systems. Excessive corti...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Institute on Alcohol Abuse and Alcoholism
1998
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761816/ https://www.ncbi.nlm.nih.gov/pubmed/15706736 |
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author | Adinoff, Bryon Iranmanesh, Ali Veldhuis, Johannes Fisher, Lisa |
author_facet | Adinoff, Bryon Iranmanesh, Ali Veldhuis, Johannes Fisher, Lisa |
author_sort | Adinoff, Bryon |
collection | PubMed |
description | Interactions among the brain, the pituitary gland, and the adrenal glands (i.e., the hypothalamic-pituitary-adrenal [HPA] axis) help regulate the body’s response to stress. The adrenal hormone cortisol plays a key role in stress reduction through its effects on multiple body systems. Excessive cortisol activity during both chronic alcohol administration and withdrawal may underlie some of the clinical complications of alcoholism, including increased risk of infectious diseases; bone, muscle, and reproductive system changes; altered energy metabolism; and disorders of mood and intellect. Despite excessive cortisol levels during intoxication and withdrawal, however, the HPA axis becomes less responsive to stress during abstinence, potentially resulting in an impaired capacity to cope with relapse-inducing stressors. |
format | Online Article Text |
id | pubmed-6761816 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1998 |
publisher | National Institute on Alcohol Abuse and Alcoholism |
record_format | MEDLINE/PubMed |
spelling | pubmed-67618162019-10-02 Disturbances of the Stress Response: The Role of the HPA Axis During Alcohol Withdrawal and Abstinence Adinoff, Bryon Iranmanesh, Ali Veldhuis, Johannes Fisher, Lisa Alcohol Health Res World Articles Interactions among the brain, the pituitary gland, and the adrenal glands (i.e., the hypothalamic-pituitary-adrenal [HPA] axis) help regulate the body’s response to stress. The adrenal hormone cortisol plays a key role in stress reduction through its effects on multiple body systems. Excessive cortisol activity during both chronic alcohol administration and withdrawal may underlie some of the clinical complications of alcoholism, including increased risk of infectious diseases; bone, muscle, and reproductive system changes; altered energy metabolism; and disorders of mood and intellect. Despite excessive cortisol levels during intoxication and withdrawal, however, the HPA axis becomes less responsive to stress during abstinence, potentially resulting in an impaired capacity to cope with relapse-inducing stressors. National Institute on Alcohol Abuse and Alcoholism 1998 /pmc/articles/PMC6761816/ /pubmed/15706736 Text en http://creativecommons.org/publicdomain/mark/1.0/ Unless otherwise noted in the text, all material appearing in this journal is in the public domain and may be reproduced without permission. Citation of the source is appreciated. |
spellingShingle | Articles Adinoff, Bryon Iranmanesh, Ali Veldhuis, Johannes Fisher, Lisa Disturbances of the Stress Response: The Role of the HPA Axis During Alcohol Withdrawal and Abstinence |
title | Disturbances of the Stress Response: The Role of the HPA Axis During Alcohol Withdrawal and Abstinence |
title_full | Disturbances of the Stress Response: The Role of the HPA Axis During Alcohol Withdrawal and Abstinence |
title_fullStr | Disturbances of the Stress Response: The Role of the HPA Axis During Alcohol Withdrawal and Abstinence |
title_full_unstemmed | Disturbances of the Stress Response: The Role of the HPA Axis During Alcohol Withdrawal and Abstinence |
title_short | Disturbances of the Stress Response: The Role of the HPA Axis During Alcohol Withdrawal and Abstinence |
title_sort | disturbances of the stress response: the role of the hpa axis during alcohol withdrawal and abstinence |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761816/ https://www.ncbi.nlm.nih.gov/pubmed/15706736 |
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