An allosteric network in spastin couples multiple activities required for microtubule severing

The AAA+ ATPase spastin remodels microtubule arrays through severing, and its mutation is the most common cause of hereditary spastic paraplegias (HSP). Polyglutamylation of the tubulin C-terminal tail recruits spastin to microtubules and modulates severing activity. Here, we present a ~3.2 Å resolu...

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Detalles Bibliográficos
Autores principales: Sandate, Colby R., Szyk, Agnieszka, Zehr, Elena, Lander, Gabriel C., Roll-Mecak, Antonina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761829/
https://www.ncbi.nlm.nih.gov/pubmed/31285604
http://dx.doi.org/10.1038/s41594-019-0257-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761829/
https://www.ncbi.nlm.nih.gov/pubmed/31285604
http://dx.doi.org/10.1038/s41594-019-0257-3

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