Using chirality to influence supramolecular gelation

Most low molecular weight gelators are chiral, with racemic mixtures often unable to form gels. Here, we show an example where all enantiomers, diastereomers and racemates of a single functionalized dipeptide can form gels. At high pH, different self-assembled aggregates are formed and these directl...

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Autores principales: McAulay, Kate, Dietrich, Bart, Su, Hao, Scott, Michael T., Rogers, Sarah, Al-Hilaly, Youssra K., Cui, Honggang, Serpell, Louise C., Seddon, Annela M., Draper, Emily R., Adams, Dave J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761870/
https://www.ncbi.nlm.nih.gov/pubmed/31588329
http://dx.doi.org/10.1039/c9sc02239b
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author McAulay, Kate
Dietrich, Bart
Su, Hao
Scott, Michael T.
Rogers, Sarah
Al-Hilaly, Youssra K.
Cui, Honggang
Serpell, Louise C.
Seddon, Annela M.
Draper, Emily R.
Adams, Dave J.
author_facet McAulay, Kate
Dietrich, Bart
Su, Hao
Scott, Michael T.
Rogers, Sarah
Al-Hilaly, Youssra K.
Cui, Honggang
Serpell, Louise C.
Seddon, Annela M.
Draper, Emily R.
Adams, Dave J.
author_sort McAulay, Kate
collection PubMed
description Most low molecular weight gelators are chiral, with racemic mixtures often unable to form gels. Here, we show an example where all enantiomers, diastereomers and racemates of a single functionalized dipeptide can form gels. At high pH, different self-assembled aggregates are formed and these directly template the structures formed in the gel. Hence, solutions and gels with different properties can be accessed simply by varying the chirality. This opens up new design rules for the field.
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spelling pubmed-67618702019-10-04 Using chirality to influence supramolecular gelation McAulay, Kate Dietrich, Bart Su, Hao Scott, Michael T. Rogers, Sarah Al-Hilaly, Youssra K. Cui, Honggang Serpell, Louise C. Seddon, Annela M. Draper, Emily R. Adams, Dave J. Chem Sci Chemistry Most low molecular weight gelators are chiral, with racemic mixtures often unable to form gels. Here, we show an example where all enantiomers, diastereomers and racemates of a single functionalized dipeptide can form gels. At high pH, different self-assembled aggregates are formed and these directly template the structures formed in the gel. Hence, solutions and gels with different properties can be accessed simply by varying the chirality. This opens up new design rules for the field. Royal Society of Chemistry 2019-07-03 /pmc/articles/PMC6761870/ /pubmed/31588329 http://dx.doi.org/10.1039/c9sc02239b Text en This journal is © The Royal Society of Chemistry 2019 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
spellingShingle Chemistry
McAulay, Kate
Dietrich, Bart
Su, Hao
Scott, Michael T.
Rogers, Sarah
Al-Hilaly, Youssra K.
Cui, Honggang
Serpell, Louise C.
Seddon, Annela M.
Draper, Emily R.
Adams, Dave J.
Using chirality to influence supramolecular gelation
title Using chirality to influence supramolecular gelation
title_full Using chirality to influence supramolecular gelation
title_fullStr Using chirality to influence supramolecular gelation
title_full_unstemmed Using chirality to influence supramolecular gelation
title_short Using chirality to influence supramolecular gelation
title_sort using chirality to influence supramolecular gelation
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761870/
https://www.ncbi.nlm.nih.gov/pubmed/31588329
http://dx.doi.org/10.1039/c9sc02239b
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