Tumour suppression by targeted intravenous non-viral CRISPRa using dendritic polymers

Aberrant gene expression is a hallmark of cancer. Although transcription is traditionally considered ‘undruggable’, the development of CRISPR-associated protein 9 (Cas9) systems offers enormous potential to rectify cancer-associated transcriptional abnormalities in malignant cells. However delivery...

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Detalles Bibliográficos
Autores principales: Kretzmann, Jessica A., Evans, Cameron W., Moses, Colette, Sorolla, Anabel, Kretzmann, Amy L., Wang, Edina, Ho, Diwei, Hackett, Mark J., Dessauvagie, Benjamin F., Smith, Nicole M., Redfern, Andrew D., Waryah, Charlene, Norret, Marck, Iyer, K. Swaminathan, Blancafort, Pilar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761875/
https://www.ncbi.nlm.nih.gov/pubmed/31588320
http://dx.doi.org/10.1039/c9sc01432b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761875/
https://www.ncbi.nlm.nih.gov/pubmed/31588320
http://dx.doi.org/10.1039/c9sc01432b

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