Driver network as a biomarker: systematic integration and network modeling of multi-omics data to derive driver signaling pathways for drug combination prediction

MOTIVATION: Drug combinations that simultaneously suppress multiple cancer driver signaling pathways increase therapeutic options and may reduce drug resistance. We have developed a computational systems biology tool, DrugComboExplorer, to identify driver signaling pathways and predict synergistic d...

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Detalles Bibliográficos
Autores principales: Huang, Lei, Brunell, David, Stephan, Clifford, Mancuso, James, Yu, Xiaohui, He, Bin, Thompson, Timothy C, Zinner, Ralph, Kim, Jeri, Davies, Peter, Wong, Stephen T C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761967/
https://www.ncbi.nlm.nih.gov/pubmed/30768150
http://dx.doi.org/10.1093/bioinformatics/btz109

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