Transcriptomic changes triggered by ouabain in rat cerebellum granule cells: Role of α3- and α1-Na(+),K(+)-ATPase-mediated signaling

It was shown previously that inhibition of the ubiquitous α1 isoform of Na(+),K(+)-ATPase by ouabain sharply affects gene expression profile via elevation of intracellular [Na(+)](i)/[K(+)](i) ratio. Unlike other cells, neurons are abundant in the α3 isoform of Na(+),K(+)-ATPase, whose affinity in r...

Descripción completa

Detalles Bibliográficos
Autores principales: Smolyaninova, Larisa V., Shiyan, Alexandra A., Kapilevich, Leonid V., Lopachev, Alexander V., Fedorova, Tatiana N., Klementieva, Tatiana S., Moskovtsev, Aleksey A., Kubatiev, Aslan A., Orlov, Sergei N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6762055/
https://www.ncbi.nlm.nih.gov/pubmed/31557202
http://dx.doi.org/10.1371/journal.pone.0222767

Ejemplares similares

Ejemplares similares