MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition

The nucleotide-binding-domain (NBD)–and leucine-rich repeat (LRR)–containing (NLR) family, pyrin-domain–containing 3 (NLRP3) inflammasome drives pathological inflammation in a suite of autoimmune, metabolic, malignant, and neurodegenerative diseases. Additionally, NLRP3 gain-of-function point mutati...

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Detalles Bibliográficos
Autores principales: Vande Walle, Lieselotte, Stowe, Irma B., Šácha, Pavel, Lee, Bettina L., Demon, Dieter, Fossoul, Amelie, Van Hauwermeiren, Filip, Saavedra, Pedro H. V., Šimon, Petr, Šubrt, Vladimír, Kostka, Libor, Stivala, Craig E., Pham, Victoria C., Staben, Steven T., Yamazoe, Sayumi, Konvalinka, Jan, Kayagaki, Nobuhiko, Lamkanfi, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6762198/
https://www.ncbi.nlm.nih.gov/pubmed/31525186
http://dx.doi.org/10.1371/journal.pbio.3000354

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