Discovery of novel West Nile Virus protease inhibitor based on isobenzonafuranone and triazolic derivatives of eugenol and indan-1,3-dione scaffolds

The West Nile Virus (WNV) NS2B-NS3 protease is an attractive target for the development of therapeutics against this arboviral pathogen. In the present investigation, the screening of a small library of fifty-eight synthetic compounds against the NS2-NB3 protease of WNV is described. The following g...

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Detalles Bibliográficos
Autores principales: de Oliveira, André S., Gazolla, Poliana A. R., Oliveira, Ana Flávia C. da S., Pereira, Wagner L., de S. Viol, Lívia C., Maia, Angélica F. da S., Santos, Edjon G., da Silva, Ítalo E. P., Mendes, Tiago A. de Oliveira, da Silva, Adalberto M., Dias, Roberto S., da Silva, Cynthia C., Polêto, Marcelo D., Teixeira, Róbson R., de Paula, Sergio O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6762200/
https://www.ncbi.nlm.nih.gov/pubmed/31557229
http://dx.doi.org/10.1371/journal.pone.0223017

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