Synthetic self-assembling ADDomer platform for highly efficient vaccination by genetically encoded multiepitope display

Self-assembling virus-like particles represent highly attractive tools for developing next-generation vaccines and protein therapeutics. We created ADDomer, an adenovirus-derived multimeric protein-based self-assembling nanoparticle scaffold engineered to facilitate plug-and-play display of multiple...

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Detalles Bibliográficos
Autores principales: Vragniau, Charles, Bufton, Joshua C., Garzoni, Frédéric, Stermann, Emilie, Rabi, Fruzsina, Terrat, Céline, Guidetti, Mélanie, Josserand, Véronique, Williams, Matt, Woods, Christopher J., Viedma, Gerardo, Bates, Phil, Verrier, Bernard, Chaperot, Laurence, Schaffitzel, Christiane, Berger, Imre, Fender, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763337/
https://www.ncbi.nlm.nih.gov/pubmed/31620562
http://dx.doi.org/10.1126/sciadv.aaw2853

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