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Detecting MYB and MYBL1 Fusion Genes in Tracheobronchial Adenoid Cystic Carcinoma by Targeted RNA-Sequencing
Primary tracheobronchial adenoid cystic carcinoma is rare, accounting for less than 1% of all lung tumors. Many adenoid cystic carcinomas have been reported to have a specific chromosome translocation t(6;9)/MYB-NFIB. More recently, t(8;9)/MYBL1-NFIB gene fusion was reported in salivary gland adenoi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763356/ https://www.ncbi.nlm.nih.gov/pubmed/31028361 http://dx.doi.org/10.1038/s41379-019-0277-x |
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author | Pei, Jianming Flieder, Douglas B. Patchefsky, Arthur Talarchek, Jacqueline N. Cooper, Harry Testa, Joseph R. Wei, Shuanzeng |
author_facet | Pei, Jianming Flieder, Douglas B. Patchefsky, Arthur Talarchek, Jacqueline N. Cooper, Harry Testa, Joseph R. Wei, Shuanzeng |
author_sort | Pei, Jianming |
collection | PubMed |
description | Primary tracheobronchial adenoid cystic carcinoma is rare, accounting for less than 1% of all lung tumors. Many adenoid cystic carcinomas have been reported to have a specific chromosome translocation t(6;9)/MYB-NFIB. More recently, t(8;9)/MYBL1-NFIB gene fusion was reported in salivary gland adenoid cystic carcinomas which lacked a t(6;9)/MYB-NFIB. Two prior studies showed t(6;9)/MYB-NFIB in tracheobronchial adenoid cystic carcinoma; however, only rare cases of MYBL1 rearrangement have been reported in this carcinoma. In this study, we used targeted RNA sequencing to investigate fusion genes in tracheobronchial adenoid cystic carcinoma at our institution. Fusions of either MYB or MYBL1 genes were detected in 7 of 7 carcinomas. Three cases had MYB-NFIB, and 3 had MYBL1-NFIB. The remaining case showed a rare MYBL1-RAD51B fusion. These findings suggest that rearrangement involving MYB or MYBL1 is a hallmark of tracheobronchial adenoid cystic carcinoma. |
format | Online Article Text |
id | pubmed-6763356 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
record_format | MEDLINE/PubMed |
spelling | pubmed-67633562019-10-25 Detecting MYB and MYBL1 Fusion Genes in Tracheobronchial Adenoid Cystic Carcinoma by Targeted RNA-Sequencing Pei, Jianming Flieder, Douglas B. Patchefsky, Arthur Talarchek, Jacqueline N. Cooper, Harry Testa, Joseph R. Wei, Shuanzeng Mod Pathol Article Primary tracheobronchial adenoid cystic carcinoma is rare, accounting for less than 1% of all lung tumors. Many adenoid cystic carcinomas have been reported to have a specific chromosome translocation t(6;9)/MYB-NFIB. More recently, t(8;9)/MYBL1-NFIB gene fusion was reported in salivary gland adenoid cystic carcinomas which lacked a t(6;9)/MYB-NFIB. Two prior studies showed t(6;9)/MYB-NFIB in tracheobronchial adenoid cystic carcinoma; however, only rare cases of MYBL1 rearrangement have been reported in this carcinoma. In this study, we used targeted RNA sequencing to investigate fusion genes in tracheobronchial adenoid cystic carcinoma at our institution. Fusions of either MYB or MYBL1 genes were detected in 7 of 7 carcinomas. Three cases had MYB-NFIB, and 3 had MYBL1-NFIB. The remaining case showed a rare MYBL1-RAD51B fusion. These findings suggest that rearrangement involving MYB or MYBL1 is a hallmark of tracheobronchial adenoid cystic carcinoma. 2019-04-25 2019-10 /pmc/articles/PMC6763356/ /pubmed/31028361 http://dx.doi.org/10.1038/s41379-019-0277-x Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Pei, Jianming Flieder, Douglas B. Patchefsky, Arthur Talarchek, Jacqueline N. Cooper, Harry Testa, Joseph R. Wei, Shuanzeng Detecting MYB and MYBL1 Fusion Genes in Tracheobronchial Adenoid Cystic Carcinoma by Targeted RNA-Sequencing |
title | Detecting MYB and MYBL1 Fusion Genes in Tracheobronchial Adenoid Cystic Carcinoma by Targeted RNA-Sequencing |
title_full | Detecting MYB and MYBL1 Fusion Genes in Tracheobronchial Adenoid Cystic Carcinoma by Targeted RNA-Sequencing |
title_fullStr | Detecting MYB and MYBL1 Fusion Genes in Tracheobronchial Adenoid Cystic Carcinoma by Targeted RNA-Sequencing |
title_full_unstemmed | Detecting MYB and MYBL1 Fusion Genes in Tracheobronchial Adenoid Cystic Carcinoma by Targeted RNA-Sequencing |
title_short | Detecting MYB and MYBL1 Fusion Genes in Tracheobronchial Adenoid Cystic Carcinoma by Targeted RNA-Sequencing |
title_sort | detecting myb and mybl1 fusion genes in tracheobronchial adenoid cystic carcinoma by targeted rna-sequencing |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763356/ https://www.ncbi.nlm.nih.gov/pubmed/31028361 http://dx.doi.org/10.1038/s41379-019-0277-x |
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