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Histone H3K27 Dimethyl Loss is Highly Specific for Malignant Peripheral Nerve Sheath Tumor and Distinguishes True PRC2 Loss from Isolated H3K27 Trimethyl Loss

Malignant peripheral nerve sheath tumors contain loss of histone H3K27 trimethylation (H3K27me3) due to driver mutations affecting the polycomb repressive complex 2 (PRC2). Consequently, loss of H3K27me3 staining has served as a diagnostic marker for this tumor type. However, recent reports demonstr...

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Detalles Bibliográficos
Autores principales:	Marchione, Dylan M, Lisby, Amanda, Viaene, Angela N, Santi, Mariarita, Nasrallah, MacLean, Wang, Li-Ping, Williams, Erik A, Larque, Ana B, Chebib, Ivan, Garcia, Benjamin A, Wojcik, John B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763358/ https://www.ncbi.nlm.nih.gov/pubmed/31175328 http://dx.doi.org/10.1038/s41379-019-0287-8

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