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Antiarrhythmic effect of the Ca(2+)-activated K(+) (SK) channel inhibitor ICA combined with either amiodarone or dofetilide in an isolated heart model of atrial fibrillation

Dose is an important parameter in terms of both efficacy and adverse effects in pharmacological treatment of atrial fibrillation (AF). Both of the class III antiarrhythmics dofetilide and amiodarone have documented anti-AF effects. While dofetilide has dose-related ventricular side effects, amiodaro...

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Detalles Bibliográficos
Autores principales:	Kirchhoff, Jeppe Egedal, Diness, Jonas Goldin, Abildgaard, Lea, Sheykhzade, Majid, Grunnet, Morten, Jespersen, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2016
Materias:	Ion Channels, Receptors and Transporters
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763419/ https://www.ncbi.nlm.nih.gov/pubmed/27722784 http://dx.doi.org/10.1007/s00424-016-1883-9

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