Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions

DNA methylation regulates gene expression in a variety of processes, including mouse embryonic development. Four catalytically active enzymes function in mice as DNA methyltransferases (Dnmts) and as transcriptional regulators. Inactivation of Dnmt3b results in mouse embryonic lethality, but which a...

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Detalles Bibliográficos
Autores principales: Nowialis, Pawel, Lopusna, Katarina, Opavska, Jana, Haney, Staci L., Abraham, Ajay, Sheng, Peike, Riva, Alberto, Natarajan, Amarnath, Guryanova, Olga, Simpson, Melanie, Hlady, Ryan, Xie, Mingyi, Opavsky, Rene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763448/
https://www.ncbi.nlm.nih.gov/pubmed/31558711
http://dx.doi.org/10.1038/s41467-019-12355-7

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