Cell necrosis, intrinsic apoptosis and senescence contribute to the progression of exencephaly to anencephaly in a mice model of congenital chranioschisis

Exencephaly/anencephaly is one of the leading causes of neonatal mortality and the most extreme open neural tube defect with no current treatments and limited mechanistic understanding. We hypothesized that exencephaly leads to a local neurodegenerative process in the brain exposed to the amniotic f...

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Detalles Bibliográficos
Autores principales: Oria, Marc, Duru, Soner, Figueira, Rebeca L., Scorletti, Federico, Turner, Lucas E., Fernandez-Alonso, Irati, Fernandez-Martin, Alejandra, Marotta, Mario, Sbragia, Lourenco, Shaaban, Aimen F., Peiro, Jose L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763477/
https://www.ncbi.nlm.nih.gov/pubmed/31558708
http://dx.doi.org/10.1038/s41419-019-1913-6

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