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Prevotella copri is associated with carboplatin-induced gut toxicity
As a widely used cancer drug, carboplatin often results in serious side effects, such as gut toxicity. In this study, we examined the effects of gut microbiota on mice with carboplatin-induced intestinal mucosal damage. Carboplatin resulted in intestinal mucositis, as indicated by weight loss, diarr...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763498/ https://www.ncbi.nlm.nih.gov/pubmed/31558709 http://dx.doi.org/10.1038/s41419-019-1963-9 |
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author | Yu, Chaoheng Zhou, Bailing Xia, Xuyang Chen, Shuang Deng, Yun Wang, Yantai Wu, Lei Tian, Yaomei Zhao, Binyan Xu, Heng Yang, Li |
author_facet | Yu, Chaoheng Zhou, Bailing Xia, Xuyang Chen, Shuang Deng, Yun Wang, Yantai Wu, Lei Tian, Yaomei Zhao, Binyan Xu, Heng Yang, Li |
author_sort | Yu, Chaoheng |
collection | PubMed |
description | As a widely used cancer drug, carboplatin often results in serious side effects, such as gut toxicity. In this study, we examined the effects of gut microbiota on mice with carboplatin-induced intestinal mucosal damage. Carboplatin resulted in intestinal mucositis, as indicated by weight loss, diarrhoea, and infiltration of inflammatory cells. It markedly increased the expression of inflammatory cytokines/chemokines in intestine. Carboplatin also altered the diversity and composition of the gut microbiota. A significantly higher abundance of Prevotella copri (P. copri) was observed in carboplatin-treated mice. Moreover, the content of P. copri was positively correlated with the severity of intestinal mucositis. Pretreatment with metronidazole reduced the content of P. copri and relieved the intestinal mucosal injury and inflammation that was induced by carboplatin. Further study revealed that supplementation with P. copri in carboplatin-treated mice resulted in more severe tissue damage, lower tight junction protein expression and higher cytokine expression, and it enhanced both local and systemic immune responses. These data demonstrated that P. copri was involved in the pathological process of carboplatin-induced intestinal mucositis, suggesting a potential attenuation of carboplatin-induced intestinal mucositis by targeting P. copri. |
format | Online Article Text |
id | pubmed-6763498 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-67634982019-09-27 Prevotella copri is associated with carboplatin-induced gut toxicity Yu, Chaoheng Zhou, Bailing Xia, Xuyang Chen, Shuang Deng, Yun Wang, Yantai Wu, Lei Tian, Yaomei Zhao, Binyan Xu, Heng Yang, Li Cell Death Dis Article As a widely used cancer drug, carboplatin often results in serious side effects, such as gut toxicity. In this study, we examined the effects of gut microbiota on mice with carboplatin-induced intestinal mucosal damage. Carboplatin resulted in intestinal mucositis, as indicated by weight loss, diarrhoea, and infiltration of inflammatory cells. It markedly increased the expression of inflammatory cytokines/chemokines in intestine. Carboplatin also altered the diversity and composition of the gut microbiota. A significantly higher abundance of Prevotella copri (P. copri) was observed in carboplatin-treated mice. Moreover, the content of P. copri was positively correlated with the severity of intestinal mucositis. Pretreatment with metronidazole reduced the content of P. copri and relieved the intestinal mucosal injury and inflammation that was induced by carboplatin. Further study revealed that supplementation with P. copri in carboplatin-treated mice resulted in more severe tissue damage, lower tight junction protein expression and higher cytokine expression, and it enhanced both local and systemic immune responses. These data demonstrated that P. copri was involved in the pathological process of carboplatin-induced intestinal mucositis, suggesting a potential attenuation of carboplatin-induced intestinal mucositis by targeting P. copri. Nature Publishing Group UK 2019-09-26 /pmc/articles/PMC6763498/ /pubmed/31558709 http://dx.doi.org/10.1038/s41419-019-1963-9 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Yu, Chaoheng Zhou, Bailing Xia, Xuyang Chen, Shuang Deng, Yun Wang, Yantai Wu, Lei Tian, Yaomei Zhao, Binyan Xu, Heng Yang, Li Prevotella copri is associated with carboplatin-induced gut toxicity |
title | Prevotella copri is associated with carboplatin-induced gut toxicity |
title_full | Prevotella copri is associated with carboplatin-induced gut toxicity |
title_fullStr | Prevotella copri is associated with carboplatin-induced gut toxicity |
title_full_unstemmed | Prevotella copri is associated with carboplatin-induced gut toxicity |
title_short | Prevotella copri is associated with carboplatin-induced gut toxicity |
title_sort | prevotella copri is associated with carboplatin-induced gut toxicity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763498/ https://www.ncbi.nlm.nih.gov/pubmed/31558709 http://dx.doi.org/10.1038/s41419-019-1963-9 |
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