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A Human Embryonic Stem Cell Model of Aβ-Dependent Chronic Progressive Neurodegeneration

We describe the construction and phenotypic analysis of a human embryonic stem cell model of progressive Aβ-dependent neurodegeneration (ND) with potential relevance to Alzheimer’s disease (AD). We modified one allele of the normal APP locus to directly express a secretory form of Aβ40 or Aβ42, enab...

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Detalles Bibliográficos
Autores principales:	Ubina, Teresa, Magallanes, Martha, Srivastava, Saumya, Warden, Charles D., Yee, Jiing-Kuan, Salvaterra, Paul M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763609/ https://www.ncbi.nlm.nih.gov/pubmed/31616241 http://dx.doi.org/10.3389/fnins.2019.01007

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