Metabolic dependency of chorismate in Plasmodium falciparum suggests an alternative source for the ubiquinone biosynthesis precursor

The shikimate pathway, a metabolic pathway absent in humans, is responsible for the production of chorismate, a branch point metabolite. In the malaria parasite, chorismate is postulated to be a direct precursor in the synthesis of p-aminobenzoic acid (folate biosynthesis), p-hydroxybenzoic acid (ub...

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Detalles Bibliográficos
Autores principales: Valenciano, Ana Lisa, Fernández-Murga, Maria L., Merino, Emilio F., Holderman, Nicole R., Butschek, Grant J., Shaffer, Karl J., Tyler, Peter C., Cassera, Maria Belen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763611/
https://www.ncbi.nlm.nih.gov/pubmed/31558748
http://dx.doi.org/10.1038/s41598-019-50319-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763611/
https://www.ncbi.nlm.nih.gov/pubmed/31558748
http://dx.doi.org/10.1038/s41598-019-50319-5

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