Non-coding RNAs as Regulators of Lymphangiogenesis in Lymphatic Development, Inflammation, and Cancer Metastasis

Non-coding RNAs (ncRNAs), which do not encode proteins, have pivotal roles in manipulating gene expression in development, physiology, and pathology. Emerging data have shown that ncRNAs can regulate lymphangiogenesis, which refers to lymphatics deriving from preexisting vessels, becomes established...

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Autores principales: Cao, Ming-xin, Tang, Ya-ling, Zhang, Wei-long, Tang, Ya-Jie, Liang, Xin-hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763613/
https://www.ncbi.nlm.nih.gov/pubmed/31616631
http://dx.doi.org/10.3389/fonc.2019.00916
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author Cao, Ming-xin
Tang, Ya-ling
Zhang, Wei-long
Tang, Ya-Jie
Liang, Xin-hua
author_facet Cao, Ming-xin
Tang, Ya-ling
Zhang, Wei-long
Tang, Ya-Jie
Liang, Xin-hua
author_sort Cao, Ming-xin
collection PubMed
description Non-coding RNAs (ncRNAs), which do not encode proteins, have pivotal roles in manipulating gene expression in development, physiology, and pathology. Emerging data have shown that ncRNAs can regulate lymphangiogenesis, which refers to lymphatics deriving from preexisting vessels, becomes established during embryogenesis, and has a close relationship with pathological conditions such as lymphatic developmental diseases, inflammation, and cancer. This review summarizes the molecular mechanisms of lymphangiogenesis in lymphatic development, inflammation and cancer metastasis, and discusses ncRNAs' regulatory effects on them. Therapeutic targets with regard to lymphangiogenesis are also discussed.
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spelling pubmed-67636132019-10-15 Non-coding RNAs as Regulators of Lymphangiogenesis in Lymphatic Development, Inflammation, and Cancer Metastasis Cao, Ming-xin Tang, Ya-ling Zhang, Wei-long Tang, Ya-Jie Liang, Xin-hua Front Oncol Oncology Non-coding RNAs (ncRNAs), which do not encode proteins, have pivotal roles in manipulating gene expression in development, physiology, and pathology. Emerging data have shown that ncRNAs can regulate lymphangiogenesis, which refers to lymphatics deriving from preexisting vessels, becomes established during embryogenesis, and has a close relationship with pathological conditions such as lymphatic developmental diseases, inflammation, and cancer. This review summarizes the molecular mechanisms of lymphangiogenesis in lymphatic development, inflammation and cancer metastasis, and discusses ncRNAs' regulatory effects on them. Therapeutic targets with regard to lymphangiogenesis are also discussed. Frontiers Media S.A. 2019-09-20 /pmc/articles/PMC6763613/ /pubmed/31616631 http://dx.doi.org/10.3389/fonc.2019.00916 Text en Copyright © 2019 Cao, Tang, Zhang, Tang and Liang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Cao, Ming-xin
Tang, Ya-ling
Zhang, Wei-long
Tang, Ya-Jie
Liang, Xin-hua
Non-coding RNAs as Regulators of Lymphangiogenesis in Lymphatic Development, Inflammation, and Cancer Metastasis
title Non-coding RNAs as Regulators of Lymphangiogenesis in Lymphatic Development, Inflammation, and Cancer Metastasis
title_full Non-coding RNAs as Regulators of Lymphangiogenesis in Lymphatic Development, Inflammation, and Cancer Metastasis
title_fullStr Non-coding RNAs as Regulators of Lymphangiogenesis in Lymphatic Development, Inflammation, and Cancer Metastasis
title_full_unstemmed Non-coding RNAs as Regulators of Lymphangiogenesis in Lymphatic Development, Inflammation, and Cancer Metastasis
title_short Non-coding RNAs as Regulators of Lymphangiogenesis in Lymphatic Development, Inflammation, and Cancer Metastasis
title_sort non-coding rnas as regulators of lymphangiogenesis in lymphatic development, inflammation, and cancer metastasis
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763613/
https://www.ncbi.nlm.nih.gov/pubmed/31616631
http://dx.doi.org/10.3389/fonc.2019.00916
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