Transmission-blocking Effects of Primaquine and Methylene Blue Suggest Plasmodium falciparum Gametocyte Sterilization Rather Than Effects on Sex Ratio

Gametocyte density and sex ratio can predict the proportion of mosquitoes that will become infected after feeding on blood of patients receiving nongametocytocidal drugs. Because primaquine and methylene blue sterilize gametocytes before affecting their density and sex ratio, mosquito feeding experi...

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Detalles Bibliográficos
Autores principales: Bradley, John, Soumaré, Harouna M, Mahamar, Almahamoudou, Diawara, Halimatou, Roh, Michelle, Delves, Michael, Drakeley, Chris, Churcher, Thomas S, Dicko, Alassane, Gosling, Roly, Bousema, Teun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763632/
https://www.ncbi.nlm.nih.gov/pubmed/30753355
http://dx.doi.org/10.1093/cid/ciz134
Descripción
Sumario:Gametocyte density and sex ratio can predict the proportion of mosquitoes that will become infected after feeding on blood of patients receiving nongametocytocidal drugs. Because primaquine and methylene blue sterilize gametocytes before affecting their density and sex ratio, mosquito feeding experiments are required to demonstrate their early transmission-blocking effects.

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