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A challenging case of concurrent multiple sclerosis and anaplastic astrocytoma
BACKGROUND: Cases of gliomas coexisting with multiple sclerosis (MS) have been described over the past few decades. However, due to the complex clinical and radiological traits inherent to both entities, this concurrent phenomenon remains difficult to diagnose. Much has been debated about whether th...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Scientific Scholar
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763678/ https://www.ncbi.nlm.nih.gov/pubmed/31583163 http://dx.doi.org/10.25259/SNI_176_2019 |
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author | Sinclair, Georges Al-saffar, Yahya Johnstone, Philippa Hatiboglu, Mustafa Aziz Shamikh, Alia |
author_facet | Sinclair, Georges Al-saffar, Yahya Johnstone, Philippa Hatiboglu, Mustafa Aziz Shamikh, Alia |
author_sort | Sinclair, Georges |
collection | PubMed |
description | BACKGROUND: Cases of gliomas coexisting with multiple sclerosis (MS) have been described over the past few decades. However, due to the complex clinical and radiological traits inherent to both entities, this concurrent phenomenon remains difficult to diagnose. Much has been debated about whether this coexistence is incidental or mirrors a poorly understood neoplastic phenomenon engaging glial cells in the regions of demyelination. CASE DESCRIPTION: We present the case of a 41-year-old patient diagnosed with a left-sided frontal contrast enhancing lesion initially assessed as a tumefactive MS. Despite systemic treatment, the patient gradually developed signs of mass effect, which led to decompressive surgery. The initial microscopic evaluation demonstrated the presence of MS and oligodendroglioma; the postoperative evolution proved complex due to a series of MS-relapses and tumor recurrence. An ulterior revaluation of the samples for the purpose of this report showed an MS-concurrent anaplastic astrocytoma. We describe all relevant clinical aspects of this case and review the medical literature for possible causal mechanisms. CONCLUSION: Although cases of concurrent glioma and MS remain rare, we present a case illustrating this phenomenon and explore a number of theories behind a potential causal relationship. |
format | Online Article Text |
id | pubmed-6763678 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Scientific Scholar |
record_format | MEDLINE/PubMed |
spelling | pubmed-67636782019-10-03 A challenging case of concurrent multiple sclerosis and anaplastic astrocytoma Sinclair, Georges Al-saffar, Yahya Johnstone, Philippa Hatiboglu, Mustafa Aziz Shamikh, Alia Surg Neurol Int Case Description BACKGROUND: Cases of gliomas coexisting with multiple sclerosis (MS) have been described over the past few decades. However, due to the complex clinical and radiological traits inherent to both entities, this concurrent phenomenon remains difficult to diagnose. Much has been debated about whether this coexistence is incidental or mirrors a poorly understood neoplastic phenomenon engaging glial cells in the regions of demyelination. CASE DESCRIPTION: We present the case of a 41-year-old patient diagnosed with a left-sided frontal contrast enhancing lesion initially assessed as a tumefactive MS. Despite systemic treatment, the patient gradually developed signs of mass effect, which led to decompressive surgery. The initial microscopic evaluation demonstrated the presence of MS and oligodendroglioma; the postoperative evolution proved complex due to a series of MS-relapses and tumor recurrence. An ulterior revaluation of the samples for the purpose of this report showed an MS-concurrent anaplastic astrocytoma. We describe all relevant clinical aspects of this case and review the medical literature for possible causal mechanisms. CONCLUSION: Although cases of concurrent glioma and MS remain rare, we present a case illustrating this phenomenon and explore a number of theories behind a potential causal relationship. Scientific Scholar 2019-08-23 /pmc/articles/PMC6763678/ /pubmed/31583163 http://dx.doi.org/10.25259/SNI_176_2019 Text en Copyright: © 2019 Surgical Neurology International http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Case Description Sinclair, Georges Al-saffar, Yahya Johnstone, Philippa Hatiboglu, Mustafa Aziz Shamikh, Alia A challenging case of concurrent multiple sclerosis and anaplastic astrocytoma |
title | A challenging case of concurrent multiple sclerosis and anaplastic astrocytoma |
title_full | A challenging case of concurrent multiple sclerosis and anaplastic astrocytoma |
title_fullStr | A challenging case of concurrent multiple sclerosis and anaplastic astrocytoma |
title_full_unstemmed | A challenging case of concurrent multiple sclerosis and anaplastic astrocytoma |
title_short | A challenging case of concurrent multiple sclerosis and anaplastic astrocytoma |
title_sort | challenging case of concurrent multiple sclerosis and anaplastic astrocytoma |
topic | Case Description |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763678/ https://www.ncbi.nlm.nih.gov/pubmed/31583163 http://dx.doi.org/10.25259/SNI_176_2019 |
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