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Mitogen-Activated Protein Kinase Signaling Mediates Morphine Induced-Delayed Hyperalgesia

The use of morphine, the standard opioid drug, is limited by its undesirable effects, such as tolerance, physical dependence, and hyperalgesia (increased pain sensitivity). Clinical and preclinical studies have reported development of hyperalgesia after prolonged opioid administration or after a sin...

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Detalles Bibliográficos
Autores principales:	de Freitas, Bárbara Guimaraes, Pereira, Leandro Márcio, Santa-Cecília, Flávia Vianna, Hösch, Natália Gabriele, Picolo, Gisele, Cury, Yara, Zambelli, Vanessa O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763729/ https://www.ncbi.nlm.nih.gov/pubmed/31616243 http://dx.doi.org/10.3389/fnins.2019.01018

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