Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development

Glycoconjugate vaccines are a critical component of the medical arsenal against infectious diseases. This established field continues, however, to experience failures in the clinic. The lack of fundamental understanding of factors controlling clinical efficacy of glycoconjugate vaccines is discussed...

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Detalles Bibliográficos
Autores principales: Avci, Fikri, Berti, Francesco, Dull, Peter, Hennessey, John, Pavliak, Viliam, Prasad, A. Krishna, Vann, Willie, Wacker, Michael, Marcq, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763769/
https://www.ncbi.nlm.nih.gov/pubmed/31554723
http://dx.doi.org/10.1128/mSphere.00520-19
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author Avci, Fikri
Berti, Francesco
Dull, Peter
Hennessey, John
Pavliak, Viliam
Prasad, A. Krishna
Vann, Willie
Wacker, Michael
Marcq, Olivier
author_facet Avci, Fikri
Berti, Francesco
Dull, Peter
Hennessey, John
Pavliak, Viliam
Prasad, A. Krishna
Vann, Willie
Wacker, Michael
Marcq, Olivier
author_sort Avci, Fikri
collection PubMed
description Glycoconjugate vaccines are a critical component of the medical arsenal against infectious diseases. This established field continues, however, to experience failures in the clinic. The lack of fundamental understanding of factors controlling clinical efficacy of glycoconjugate vaccines is discussed while key parameters demanding focused and collaborative research are identified.
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spelling pubmed-67637692019-10-15 Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development Avci, Fikri Berti, Francesco Dull, Peter Hennessey, John Pavliak, Viliam Prasad, A. Krishna Vann, Willie Wacker, Michael Marcq, Olivier mSphere Perspective Glycoconjugate vaccines are a critical component of the medical arsenal against infectious diseases. This established field continues, however, to experience failures in the clinic. The lack of fundamental understanding of factors controlling clinical efficacy of glycoconjugate vaccines is discussed while key parameters demanding focused and collaborative research are identified. American Society for Microbiology 2019-09-25 /pmc/articles/PMC6763769/ /pubmed/31554723 http://dx.doi.org/10.1128/mSphere.00520-19 Text en Copyright © 2019 Avci et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Perspective
Avci, Fikri
Berti, Francesco
Dull, Peter
Hennessey, John
Pavliak, Viliam
Prasad, A. Krishna
Vann, Willie
Wacker, Michael
Marcq, Olivier
Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development
title Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development
title_full Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development
title_fullStr Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development
title_full_unstemmed Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development
title_short Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development
title_sort glycoconjugates: what it would take to master these well-known yet little-understood immunogens for vaccine development
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763769/
https://www.ncbi.nlm.nih.gov/pubmed/31554723
http://dx.doi.org/10.1128/mSphere.00520-19
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