Cargando…
Extracellular Matrices to Modulate the Innate Immune Response and Enhance Bone Healing
Extracellular matrices (ECMs) have emerged as promising off-the-shelf products to induce bone regeneration, with the capacity not only to activate osteoprogenitors, but also to influence the immune response. ECMs generated starting from living cells such as mesenchymal stromal cells (MSCs) have the...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764079/ https://www.ncbi.nlm.nih.gov/pubmed/31616429 http://dx.doi.org/10.3389/fimmu.2019.02256 |
_version_ | 1783454301083926528 |
---|---|
author | García-García, Andrés Martin, Ivan |
author_facet | García-García, Andrés Martin, Ivan |
author_sort | García-García, Andrés |
collection | PubMed |
description | Extracellular matrices (ECMs) have emerged as promising off-the-shelf products to induce bone regeneration, with the capacity not only to activate osteoprogenitors, but also to influence the immune response. ECMs generated starting from living cells such as mesenchymal stromal cells (MSCs) have the potential to combine advantages of native tissue-derived ECMs (e.g., physiological presentation of multiple regulatory factors) with those of synthetic ECMs (e.g., customization and reproducibility of composition). MSC-derived ECMs could be tailored by enrichment not only in osteogenic cytokines, but also in immunomodulatory factors, to skew the innate immune response toward regenerative processes. After reviewing the different immunoregulatory properties of ECM components, here we propose different approaches to engineer ECMs enriched in factors capable to regulate macrophage polarization, recruit host immune and mesenchymal cells, and stimulate the synthesis of other immunoinstructive cytokines. Finally, we offer a perspective on the possible evolution of the paradigm based on biological and chemico-physical design considerations, and the use of gene editing approaches. |
format | Online Article Text |
id | pubmed-6764079 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67640792019-10-15 Extracellular Matrices to Modulate the Innate Immune Response and Enhance Bone Healing García-García, Andrés Martin, Ivan Front Immunol Immunology Extracellular matrices (ECMs) have emerged as promising off-the-shelf products to induce bone regeneration, with the capacity not only to activate osteoprogenitors, but also to influence the immune response. ECMs generated starting from living cells such as mesenchymal stromal cells (MSCs) have the potential to combine advantages of native tissue-derived ECMs (e.g., physiological presentation of multiple regulatory factors) with those of synthetic ECMs (e.g., customization and reproducibility of composition). MSC-derived ECMs could be tailored by enrichment not only in osteogenic cytokines, but also in immunomodulatory factors, to skew the innate immune response toward regenerative processes. After reviewing the different immunoregulatory properties of ECM components, here we propose different approaches to engineer ECMs enriched in factors capable to regulate macrophage polarization, recruit host immune and mesenchymal cells, and stimulate the synthesis of other immunoinstructive cytokines. Finally, we offer a perspective on the possible evolution of the paradigm based on biological and chemico-physical design considerations, and the use of gene editing approaches. Frontiers Media S.A. 2019-09-20 /pmc/articles/PMC6764079/ /pubmed/31616429 http://dx.doi.org/10.3389/fimmu.2019.02256 Text en Copyright © 2019 García-García and Martin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology García-García, Andrés Martin, Ivan Extracellular Matrices to Modulate the Innate Immune Response and Enhance Bone Healing |
title | Extracellular Matrices to Modulate the Innate Immune Response and Enhance Bone Healing |
title_full | Extracellular Matrices to Modulate the Innate Immune Response and Enhance Bone Healing |
title_fullStr | Extracellular Matrices to Modulate the Innate Immune Response and Enhance Bone Healing |
title_full_unstemmed | Extracellular Matrices to Modulate the Innate Immune Response and Enhance Bone Healing |
title_short | Extracellular Matrices to Modulate the Innate Immune Response and Enhance Bone Healing |
title_sort | extracellular matrices to modulate the innate immune response and enhance bone healing |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764079/ https://www.ncbi.nlm.nih.gov/pubmed/31616429 http://dx.doi.org/10.3389/fimmu.2019.02256 |
work_keys_str_mv | AT garciagarciaandres extracellularmatricestomodulatetheinnateimmuneresponseandenhancebonehealing AT martinivan extracellularmatricestomodulatetheinnateimmuneresponseandenhancebonehealing |