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Extracellular Matrices to Modulate the Innate Immune Response and Enhance Bone Healing

Extracellular matrices (ECMs) have emerged as promising off-the-shelf products to induce bone regeneration, with the capacity not only to activate osteoprogenitors, but also to influence the immune response. ECMs generated starting from living cells such as mesenchymal stromal cells (MSCs) have the...

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Detalles Bibliográficos
Autores principales: García-García, Andrés, Martin, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764079/
https://www.ncbi.nlm.nih.gov/pubmed/31616429
http://dx.doi.org/10.3389/fimmu.2019.02256
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author García-García, Andrés
Martin, Ivan
author_facet García-García, Andrés
Martin, Ivan
author_sort García-García, Andrés
collection PubMed
description Extracellular matrices (ECMs) have emerged as promising off-the-shelf products to induce bone regeneration, with the capacity not only to activate osteoprogenitors, but also to influence the immune response. ECMs generated starting from living cells such as mesenchymal stromal cells (MSCs) have the potential to combine advantages of native tissue-derived ECMs (e.g., physiological presentation of multiple regulatory factors) with those of synthetic ECMs (e.g., customization and reproducibility of composition). MSC-derived ECMs could be tailored by enrichment not only in osteogenic cytokines, but also in immunomodulatory factors, to skew the innate immune response toward regenerative processes. After reviewing the different immunoregulatory properties of ECM components, here we propose different approaches to engineer ECMs enriched in factors capable to regulate macrophage polarization, recruit host immune and mesenchymal cells, and stimulate the synthesis of other immunoinstructive cytokines. Finally, we offer a perspective on the possible evolution of the paradigm based on biological and chemico-physical design considerations, and the use of gene editing approaches.
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spelling pubmed-67640792019-10-15 Extracellular Matrices to Modulate the Innate Immune Response and Enhance Bone Healing García-García, Andrés Martin, Ivan Front Immunol Immunology Extracellular matrices (ECMs) have emerged as promising off-the-shelf products to induce bone regeneration, with the capacity not only to activate osteoprogenitors, but also to influence the immune response. ECMs generated starting from living cells such as mesenchymal stromal cells (MSCs) have the potential to combine advantages of native tissue-derived ECMs (e.g., physiological presentation of multiple regulatory factors) with those of synthetic ECMs (e.g., customization and reproducibility of composition). MSC-derived ECMs could be tailored by enrichment not only in osteogenic cytokines, but also in immunomodulatory factors, to skew the innate immune response toward regenerative processes. After reviewing the different immunoregulatory properties of ECM components, here we propose different approaches to engineer ECMs enriched in factors capable to regulate macrophage polarization, recruit host immune and mesenchymal cells, and stimulate the synthesis of other immunoinstructive cytokines. Finally, we offer a perspective on the possible evolution of the paradigm based on biological and chemico-physical design considerations, and the use of gene editing approaches. Frontiers Media S.A. 2019-09-20 /pmc/articles/PMC6764079/ /pubmed/31616429 http://dx.doi.org/10.3389/fimmu.2019.02256 Text en Copyright © 2019 García-García and Martin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
García-García, Andrés
Martin, Ivan
Extracellular Matrices to Modulate the Innate Immune Response and Enhance Bone Healing
title Extracellular Matrices to Modulate the Innate Immune Response and Enhance Bone Healing
title_full Extracellular Matrices to Modulate the Innate Immune Response and Enhance Bone Healing
title_fullStr Extracellular Matrices to Modulate the Innate Immune Response and Enhance Bone Healing
title_full_unstemmed Extracellular Matrices to Modulate the Innate Immune Response and Enhance Bone Healing
title_short Extracellular Matrices to Modulate the Innate Immune Response and Enhance Bone Healing
title_sort extracellular matrices to modulate the innate immune response and enhance bone healing
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764079/
https://www.ncbi.nlm.nih.gov/pubmed/31616429
http://dx.doi.org/10.3389/fimmu.2019.02256
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