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Baricitinib reverses HIV-associated neurocognitive disorders in a SCID mouse model and reservoir seeding in vitro

BACKGROUND: Since HIV-associated neurocognitive disorders (HANDs) occur in up to half of HIV-positive individuals, even with combined antiretroviral therapy (cART), adjunctive therapies are needed. Chronic CNS inflammation contributes to HAND and HIV encephalitis (HIVE). Baricitinib is a JAK 1/2 inh...

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Detalles Bibliográficos
Autores principales:	Gavegnano, Christina, Haile, Woldeab B., Hurwitz, Selwyn, Tao, Sijia, Jiang, Yong, Schinazi, Raymond F., Tyor, William R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764124/ https://www.ncbi.nlm.nih.gov/pubmed/31561750 http://dx.doi.org/10.1186/s12974-019-1565-6

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