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The impact of C-reactive protein levels on headache frequency in the HUNT study 2006–2008

BACKGROUND: Increased high sensitivity C- reactive protein (hs-CRP) levels have been found in many earlier studies on migraine, and recently also in persons with migraine and insomnia. The aim of this study was to see whether these findings could be reproduced in a large-scale population-based study...

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Autores principales: Hagen, Knut, Stovner, Lars Jacob, Nilsen, Kristian Bernhard, Kristoffersen, Espen Saxhaug, Winsvold, Bendik Slagsvold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764126/
https://www.ncbi.nlm.nih.gov/pubmed/31558164
http://dx.doi.org/10.1186/s12883-019-1462-8
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author Hagen, Knut
Stovner, Lars Jacob
Nilsen, Kristian Bernhard
Kristoffersen, Espen Saxhaug
Winsvold, Bendik Slagsvold
author_facet Hagen, Knut
Stovner, Lars Jacob
Nilsen, Kristian Bernhard
Kristoffersen, Espen Saxhaug
Winsvold, Bendik Slagsvold
author_sort Hagen, Knut
collection PubMed
description BACKGROUND: Increased high sensitivity C- reactive protein (hs-CRP) levels have been found in many earlier studies on migraine, and recently also in persons with migraine and insomnia. The aim of this study was to see whether these findings could be reproduced in a large-scale population-based study. METHODS: A total of 50,807 (54%) out of 94,194 invited aged ≥20 years or older participated in the third wave of the Nord-Trøndelag Health Study study performed in 2006–2008. Among these, 38,807 (41%) had valid measures of hs-CRP and answered questions on headache and insomnia. Elevated hs-CRP was defined as > 3.0 mg/L. The cross-sectional association with headache was estimated by multivariate analyses using multiple logistic regression. The precision of the odds ratio (OR) was assessed with 95% confidence interval (CI). RESULTS: In the fully adjusted model, elevated hs-CRP was associated with migraine (OR 1.14, 95% CI 1.04–1.25) and migraine with aura (OR 1.15, 95% CI 1.03–1.29). The association was strongest among individuals with headache ≥15 days/month for any headache (OR 1.26, 95% CI 1.08–1.48), migraine (OR 1.62, 95% CI 1.21–2.17), and migraine with aura (OR 1.84, 95% CI 1.27–2.67). No clear relationship was found between elevated hs-CRP and headache less than 7 days/month or with insomnia. CONCLUSIONS: Cross-sectional data from this large-scale population-based study showed that elevated hs-CRP was associated with headache ≥7 days/month, especially evident for migraine with aura.
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spelling pubmed-67641262019-09-30 The impact of C-reactive protein levels on headache frequency in the HUNT study 2006–2008 Hagen, Knut Stovner, Lars Jacob Nilsen, Kristian Bernhard Kristoffersen, Espen Saxhaug Winsvold, Bendik Slagsvold BMC Neurol Research Article BACKGROUND: Increased high sensitivity C- reactive protein (hs-CRP) levels have been found in many earlier studies on migraine, and recently also in persons with migraine and insomnia. The aim of this study was to see whether these findings could be reproduced in a large-scale population-based study. METHODS: A total of 50,807 (54%) out of 94,194 invited aged ≥20 years or older participated in the third wave of the Nord-Trøndelag Health Study study performed in 2006–2008. Among these, 38,807 (41%) had valid measures of hs-CRP and answered questions on headache and insomnia. Elevated hs-CRP was defined as > 3.0 mg/L. The cross-sectional association with headache was estimated by multivariate analyses using multiple logistic regression. The precision of the odds ratio (OR) was assessed with 95% confidence interval (CI). RESULTS: In the fully adjusted model, elevated hs-CRP was associated with migraine (OR 1.14, 95% CI 1.04–1.25) and migraine with aura (OR 1.15, 95% CI 1.03–1.29). The association was strongest among individuals with headache ≥15 days/month for any headache (OR 1.26, 95% CI 1.08–1.48), migraine (OR 1.62, 95% CI 1.21–2.17), and migraine with aura (OR 1.84, 95% CI 1.27–2.67). No clear relationship was found between elevated hs-CRP and headache less than 7 days/month or with insomnia. CONCLUSIONS: Cross-sectional data from this large-scale population-based study showed that elevated hs-CRP was associated with headache ≥7 days/month, especially evident for migraine with aura. BioMed Central 2019-09-26 /pmc/articles/PMC6764126/ /pubmed/31558164 http://dx.doi.org/10.1186/s12883-019-1462-8 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Hagen, Knut
Stovner, Lars Jacob
Nilsen, Kristian Bernhard
Kristoffersen, Espen Saxhaug
Winsvold, Bendik Slagsvold
The impact of C-reactive protein levels on headache frequency in the HUNT study 2006–2008
title The impact of C-reactive protein levels on headache frequency in the HUNT study 2006–2008
title_full The impact of C-reactive protein levels on headache frequency in the HUNT study 2006–2008
title_fullStr The impact of C-reactive protein levels on headache frequency in the HUNT study 2006–2008
title_full_unstemmed The impact of C-reactive protein levels on headache frequency in the HUNT study 2006–2008
title_short The impact of C-reactive protein levels on headache frequency in the HUNT study 2006–2008
title_sort impact of c-reactive protein levels on headache frequency in the hunt study 2006–2008
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764126/
https://www.ncbi.nlm.nih.gov/pubmed/31558164
http://dx.doi.org/10.1186/s12883-019-1462-8
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