Characterization of Reactive Organometallic Species via MicroED

[Image: see text] Here we apply microcrystal electron diffraction (MicroED) to the structural determination of transition-metal complexes. We find that the simultaneous use of 300 keV electrons, very low electron doses, and an ultrasensitive camera allows for the collection of data without cryogenic...

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Autores principales: Jones, Christopher G., Asay, Matthew, Kim, Lee Joon, Kleinsasser, Jack F., Saha, Ambarneil, Fulton, Tyler J., Berkley, Kevin R., Cascio, Duilio, Malyutin, Andrey G., Conley, Matthew P., Stoltz, Brian M., Lavallo, Vincent, Rodríguez, José A., Nelson, Hosea M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764211/
https://www.ncbi.nlm.nih.gov/pubmed/31572777
http://dx.doi.org/10.1021/acscentsci.9b00403
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author Jones, Christopher G.
Asay, Matthew
Kim, Lee Joon
Kleinsasser, Jack F.
Saha, Ambarneil
Fulton, Tyler J.
Berkley, Kevin R.
Cascio, Duilio
Malyutin, Andrey G.
Conley, Matthew P.
Stoltz, Brian M.
Lavallo, Vincent
Rodríguez, José A.
Nelson, Hosea M.
author_facet Jones, Christopher G.
Asay, Matthew
Kim, Lee Joon
Kleinsasser, Jack F.
Saha, Ambarneil
Fulton, Tyler J.
Berkley, Kevin R.
Cascio, Duilio
Malyutin, Andrey G.
Conley, Matthew P.
Stoltz, Brian M.
Lavallo, Vincent
Rodríguez, José A.
Nelson, Hosea M.
author_sort Jones, Christopher G.
collection PubMed
description [Image: see text] Here we apply microcrystal electron diffraction (MicroED) to the structural determination of transition-metal complexes. We find that the simultaneous use of 300 keV electrons, very low electron doses, and an ultrasensitive camera allows for the collection of data without cryogenic cooling of the stage. This technique reveals the first crystal structures of the classic zirconocene hydride, colloquially known as “Schwartz’s reagent”, a novel Pd(II) complex not amenable to solution-state NMR or X-ray crystallography, and five other paramagnetic and diamagnetic transition-metal complexes.
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spelling pubmed-67642112019-09-30 Characterization of Reactive Organometallic Species via MicroED Jones, Christopher G. Asay, Matthew Kim, Lee Joon Kleinsasser, Jack F. Saha, Ambarneil Fulton, Tyler J. Berkley, Kevin R. Cascio, Duilio Malyutin, Andrey G. Conley, Matthew P. Stoltz, Brian M. Lavallo, Vincent Rodríguez, José A. Nelson, Hosea M. ACS Cent Sci [Image: see text] Here we apply microcrystal electron diffraction (MicroED) to the structural determination of transition-metal complexes. We find that the simultaneous use of 300 keV electrons, very low electron doses, and an ultrasensitive camera allows for the collection of data without cryogenic cooling of the stage. This technique reveals the first crystal structures of the classic zirconocene hydride, colloquially known as “Schwartz’s reagent”, a novel Pd(II) complex not amenable to solution-state NMR or X-ray crystallography, and five other paramagnetic and diamagnetic transition-metal complexes. American Chemical Society 2019-09-06 2019-09-25 /pmc/articles/PMC6764211/ /pubmed/31572777 http://dx.doi.org/10.1021/acscentsci.9b00403 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Jones, Christopher G.
Asay, Matthew
Kim, Lee Joon
Kleinsasser, Jack F.
Saha, Ambarneil
Fulton, Tyler J.
Berkley, Kevin R.
Cascio, Duilio
Malyutin, Andrey G.
Conley, Matthew P.
Stoltz, Brian M.
Lavallo, Vincent
Rodríguez, José A.
Nelson, Hosea M.
Characterization of Reactive Organometallic Species via MicroED
title Characterization of Reactive Organometallic Species via MicroED
title_full Characterization of Reactive Organometallic Species via MicroED
title_fullStr Characterization of Reactive Organometallic Species via MicroED
title_full_unstemmed Characterization of Reactive Organometallic Species via MicroED
title_short Characterization of Reactive Organometallic Species via MicroED
title_sort characterization of reactive organometallic species via microed
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764211/
https://www.ncbi.nlm.nih.gov/pubmed/31572777
http://dx.doi.org/10.1021/acscentsci.9b00403
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