Construction of a Fluorescent Screening System of Allosteric Modulators for the GABA(A) Receptor Using a Turn-On Probe

[Image: see text] γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system. The fast inhibitory actions of GABA are mainly mediated by GABA(A) receptors (GABA(A)Rs), which are widely recognized as clinically relevant drug targets. However, it remains difficul...

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Autores principales: Sakamoto, Seiji, Yamaura, Kei, Numata, Tomohiro, Harada, Fumio, Amaike, Kazuma, Inoue, Ryuji, Kiyonaka, Shigeki, Hamachi, Itaru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764212/
https://www.ncbi.nlm.nih.gov/pubmed/31572781
http://dx.doi.org/10.1021/acscentsci.9b00539

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