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Comparison of Clinical, Metabolic, Hormonal, and Ultrasound Parameters among the Clomiphene Citrate-Resistant and Clomiphene Citrate-Sensitive Polycystic Ovary Syndrome Women

OBJECTIVE: The objective of the study is to compare the clinical, metabolic, hormonal, and ultrasound parameters among the clomiphene citrate (CC)-sensitive and CC-resistant polycystic ovary syndrome (PCOS) women. MATERIALS AND METHODS: This was a prospective observational study. SETTING: The study...

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Autores principales: Sachdeva, Garima, Gainder, Shalini, Suri, Vanita, Sachdeva, Naresh, Chopra, Seema
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764232/
https://www.ncbi.nlm.nih.gov/pubmed/31576079
http://dx.doi.org/10.4103/jhrs.JHRS_89_18
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author Sachdeva, Garima
Gainder, Shalini
Suri, Vanita
Sachdeva, Naresh
Chopra, Seema
author_facet Sachdeva, Garima
Gainder, Shalini
Suri, Vanita
Sachdeva, Naresh
Chopra, Seema
author_sort Sachdeva, Garima
collection PubMed
description OBJECTIVE: The objective of the study is to compare the clinical, metabolic, hormonal, and ultrasound parameters among the clomiphene citrate (CC)-sensitive and CC-resistant polycystic ovary syndrome (PCOS) women. MATERIALS AND METHODS: This was a prospective observational study. SETTING: The study was conducted at the infertility outpatient department in a government hospital. SAMPLE SIZE: A total of 164 women with PCOS-related infertility were included. INTERVENTION: Incremental dose of CC from 50 mg/day to 100 mg/day to 150 mg/day over three cycles was given. RESPONSE: Ovulation was the outcome. Those who failed to ovulate with 150 mg CC were CC resistant. RESULTS: Of the total 164 PCOS women, 88 (53.7%) were CC resistant and 76 (46.3%) were CC sensitive. Of the 76 PCOS women who ovulated, maximum, i.e., 37 (22.6%) women ovulated with 100 mg CC. The most common diagnostic feature of PCOS in this study was hyperandrogenism (96.3%). CC-resistant PCOS women had significantly higher weight, waist circumference, waist-hip ratio, and body mass index (BMI). Significantly longer menstrual cycles and hyperandrogenism were significantly more common in CC-resistant group. CC-resistant group had a significantly higher ovarian reserve (ovarian volume, antral follicle count, and anti-Müllerian hormone values). Baseline luteinizing hormone (LH) values and LH-follicle stimulating hormone ratio were significantly higher in the CC-resistant group. CONCLUSION: Clomiphene-resistant PCOS women have significantly higher hyperandrogenism, longer cycles, more deranged metabolic profile, higher BMI, and ovarian reserve. These differences should be kept in mind while deciding the ovulation induction protocol.
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spelling pubmed-67642322019-10-01 Comparison of Clinical, Metabolic, Hormonal, and Ultrasound Parameters among the Clomiphene Citrate-Resistant and Clomiphene Citrate-Sensitive Polycystic Ovary Syndrome Women Sachdeva, Garima Gainder, Shalini Suri, Vanita Sachdeva, Naresh Chopra, Seema J Hum Reprod Sci Original Article OBJECTIVE: The objective of the study is to compare the clinical, metabolic, hormonal, and ultrasound parameters among the clomiphene citrate (CC)-sensitive and CC-resistant polycystic ovary syndrome (PCOS) women. MATERIALS AND METHODS: This was a prospective observational study. SETTING: The study was conducted at the infertility outpatient department in a government hospital. SAMPLE SIZE: A total of 164 women with PCOS-related infertility were included. INTERVENTION: Incremental dose of CC from 50 mg/day to 100 mg/day to 150 mg/day over three cycles was given. RESPONSE: Ovulation was the outcome. Those who failed to ovulate with 150 mg CC were CC resistant. RESULTS: Of the total 164 PCOS women, 88 (53.7%) were CC resistant and 76 (46.3%) were CC sensitive. Of the 76 PCOS women who ovulated, maximum, i.e., 37 (22.6%) women ovulated with 100 mg CC. The most common diagnostic feature of PCOS in this study was hyperandrogenism (96.3%). CC-resistant PCOS women had significantly higher weight, waist circumference, waist-hip ratio, and body mass index (BMI). Significantly longer menstrual cycles and hyperandrogenism were significantly more common in CC-resistant group. CC-resistant group had a significantly higher ovarian reserve (ovarian volume, antral follicle count, and anti-Müllerian hormone values). Baseline luteinizing hormone (LH) values and LH-follicle stimulating hormone ratio were significantly higher in the CC-resistant group. CONCLUSION: Clomiphene-resistant PCOS women have significantly higher hyperandrogenism, longer cycles, more deranged metabolic profile, higher BMI, and ovarian reserve. These differences should be kept in mind while deciding the ovulation induction protocol. Wolters Kluwer - Medknow 2019 /pmc/articles/PMC6764232/ /pubmed/31576079 http://dx.doi.org/10.4103/jhrs.JHRS_89_18 Text en Copyright: © 2019 Journal of Human Reproductive Sciences http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Sachdeva, Garima
Gainder, Shalini
Suri, Vanita
Sachdeva, Naresh
Chopra, Seema
Comparison of Clinical, Metabolic, Hormonal, and Ultrasound Parameters among the Clomiphene Citrate-Resistant and Clomiphene Citrate-Sensitive Polycystic Ovary Syndrome Women
title Comparison of Clinical, Metabolic, Hormonal, and Ultrasound Parameters among the Clomiphene Citrate-Resistant and Clomiphene Citrate-Sensitive Polycystic Ovary Syndrome Women
title_full Comparison of Clinical, Metabolic, Hormonal, and Ultrasound Parameters among the Clomiphene Citrate-Resistant and Clomiphene Citrate-Sensitive Polycystic Ovary Syndrome Women
title_fullStr Comparison of Clinical, Metabolic, Hormonal, and Ultrasound Parameters among the Clomiphene Citrate-Resistant and Clomiphene Citrate-Sensitive Polycystic Ovary Syndrome Women
title_full_unstemmed Comparison of Clinical, Metabolic, Hormonal, and Ultrasound Parameters among the Clomiphene Citrate-Resistant and Clomiphene Citrate-Sensitive Polycystic Ovary Syndrome Women
title_short Comparison of Clinical, Metabolic, Hormonal, and Ultrasound Parameters among the Clomiphene Citrate-Resistant and Clomiphene Citrate-Sensitive Polycystic Ovary Syndrome Women
title_sort comparison of clinical, metabolic, hormonal, and ultrasound parameters among the clomiphene citrate-resistant and clomiphene citrate-sensitive polycystic ovary syndrome women
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764232/
https://www.ncbi.nlm.nih.gov/pubmed/31576079
http://dx.doi.org/10.4103/jhrs.JHRS_89_18
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