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Association of retinol binding protein-4, cystatin C, homocysteine and high-sensitivity C-reactive protein levels in patients with newly diagnosed type 2 diabetes mellitus

INTRODUCTION: To investigate the serum retinol binding protein (RBP)-4, cystatin C (Cys C), homocysteine (HCY) and high-sensitivity C-reactive protein (hs-CRP) levels in newly diagnosed type 2 diabetes mellitus (NT2DM) patients, prediabetes mellitus (PDM) subjects and normal controls, as well as the...

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Autores principales: Wang, Yun-Sheng, Ye, Jun, Yang, Xiao, Zhang, Gui-Ping, Cao, Yong-Hong, Zhang, Rong, Dai, Wu, Zhang, Qiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764307/
https://www.ncbi.nlm.nih.gov/pubmed/31572465
http://dx.doi.org/10.5114/aoms.2018.79565
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author Wang, Yun-Sheng
Ye, Jun
Yang, Xiao
Zhang, Gui-Ping
Cao, Yong-Hong
Zhang, Rong
Dai, Wu
Zhang, Qiu
author_facet Wang, Yun-Sheng
Ye, Jun
Yang, Xiao
Zhang, Gui-Ping
Cao, Yong-Hong
Zhang, Rong
Dai, Wu
Zhang, Qiu
author_sort Wang, Yun-Sheng
collection PubMed
description INTRODUCTION: To investigate the serum retinol binding protein (RBP)-4, cystatin C (Cys C), homocysteine (HCY) and high-sensitivity C-reactive protein (hs-CRP) levels in newly diagnosed type 2 diabetes mellitus (NT2DM) patients, prediabetes mellitus (PDM) subjects and normal controls, as well as their correlation with clinical and laboratory indexes, such as blood pressure and lipoprotein. MATERIAL AND METHODS: A total of 242 subjects, including 141 NT2DM patients, 48 PDM subjects and 53 healthy controls, were recruited in the present study. Serum RBP-4, Cys C and hs-CRP concentrations were measured by enzyme-linked immunosorbent assay (ELISA). HCY concentration was determined by the chemical luminescence method. RESULTS: There were significant differences in Cys C and hs-CRP among NT2DM patients, PDM subjects and normal controls. In comparison to controls, there were significantly elevated Cys C and hs-CRP levels in PDM (both p < 0.001), and a significantly increased Cys C level in NT2DM (p < 0.001); however, there were no significant differences in Cys C and hs-CRP levels between NT2DM and PDM, and no significant differences of hs-CRP levels between NT2DM and normal controls. No significant differences of RBP-4 and HCY levels among NT2DM, PDM and normal control groups were observed. CONCLUSIONS: Aberrant Cys C expression and its clinical associations in NT2DM suggest their important role in this disease.
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spelling pubmed-67643072019-09-30 Association of retinol binding protein-4, cystatin C, homocysteine and high-sensitivity C-reactive protein levels in patients with newly diagnosed type 2 diabetes mellitus Wang, Yun-Sheng Ye, Jun Yang, Xiao Zhang, Gui-Ping Cao, Yong-Hong Zhang, Rong Dai, Wu Zhang, Qiu Arch Med Sci Clinical Research INTRODUCTION: To investigate the serum retinol binding protein (RBP)-4, cystatin C (Cys C), homocysteine (HCY) and high-sensitivity C-reactive protein (hs-CRP) levels in newly diagnosed type 2 diabetes mellitus (NT2DM) patients, prediabetes mellitus (PDM) subjects and normal controls, as well as their correlation with clinical and laboratory indexes, such as blood pressure and lipoprotein. MATERIAL AND METHODS: A total of 242 subjects, including 141 NT2DM patients, 48 PDM subjects and 53 healthy controls, were recruited in the present study. Serum RBP-4, Cys C and hs-CRP concentrations were measured by enzyme-linked immunosorbent assay (ELISA). HCY concentration was determined by the chemical luminescence method. RESULTS: There were significant differences in Cys C and hs-CRP among NT2DM patients, PDM subjects and normal controls. In comparison to controls, there were significantly elevated Cys C and hs-CRP levels in PDM (both p < 0.001), and a significantly increased Cys C level in NT2DM (p < 0.001); however, there were no significant differences in Cys C and hs-CRP levels between NT2DM and PDM, and no significant differences of hs-CRP levels between NT2DM and normal controls. No significant differences of RBP-4 and HCY levels among NT2DM, PDM and normal control groups were observed. CONCLUSIONS: Aberrant Cys C expression and its clinical associations in NT2DM suggest their important role in this disease. Termedia Publishing House 2018-11-13 2019-09 /pmc/articles/PMC6764307/ /pubmed/31572465 http://dx.doi.org/10.5114/aoms.2018.79565 Text en Copyright: © 2018 Termedia & Banach http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Clinical Research
Wang, Yun-Sheng
Ye, Jun
Yang, Xiao
Zhang, Gui-Ping
Cao, Yong-Hong
Zhang, Rong
Dai, Wu
Zhang, Qiu
Association of retinol binding protein-4, cystatin C, homocysteine and high-sensitivity C-reactive protein levels in patients with newly diagnosed type 2 diabetes mellitus
title Association of retinol binding protein-4, cystatin C, homocysteine and high-sensitivity C-reactive protein levels in patients with newly diagnosed type 2 diabetes mellitus
title_full Association of retinol binding protein-4, cystatin C, homocysteine and high-sensitivity C-reactive protein levels in patients with newly diagnosed type 2 diabetes mellitus
title_fullStr Association of retinol binding protein-4, cystatin C, homocysteine and high-sensitivity C-reactive protein levels in patients with newly diagnosed type 2 diabetes mellitus
title_full_unstemmed Association of retinol binding protein-4, cystatin C, homocysteine and high-sensitivity C-reactive protein levels in patients with newly diagnosed type 2 diabetes mellitus
title_short Association of retinol binding protein-4, cystatin C, homocysteine and high-sensitivity C-reactive protein levels in patients with newly diagnosed type 2 diabetes mellitus
title_sort association of retinol binding protein-4, cystatin c, homocysteine and high-sensitivity c-reactive protein levels in patients with newly diagnosed type 2 diabetes mellitus
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764307/
https://www.ncbi.nlm.nih.gov/pubmed/31572465
http://dx.doi.org/10.5114/aoms.2018.79565
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