Combination of leflunomide and benazepril reduces renal injury of diabetic nephropathy rats and inhibits high-glucose induced cell apoptosis through regulation of NF-κB, TGF-β and TRPC6

Objective: To investigate effects of combination use of leflunomide and benazepril on diabetic nephropathy (DN) both in vivo and in vitro. Methods: The streptozotocin (STZ) induced Sprague-Dawley rats were treated with leflunomide (15 mg/kg/d), benazepril (15 mg/kg/d) or both the two drugs. Fasting...

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Detalles Bibliográficos
Autores principales: Li, Huili, Wang, Yuanyuan, Zhou, Zhangqing, Tian, Fang, Yang, Huanhuan, Yan, Juzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Laboratory Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764370/
https://www.ncbi.nlm.nih.gov/pubmed/31552773
http://dx.doi.org/10.1080/0886022X.2019.1665547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764370/
https://www.ncbi.nlm.nih.gov/pubmed/31552773
http://dx.doi.org/10.1080/0886022X.2019.1665547

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