Cargando…

Dexmedetomidine Attenuates Neuroinflammatory–Induced Apoptosis after Traumatic Brain Injury via Nrf2 signaling pathway

OBJECTIVE: Dexmedetomidine (DEX) exhibits neuroprotective effects as a multifunctional neuroprotective agent in numerous neurological disorders. However, in traumatic brain injury (TBI), the molecular mechanisms of these neuroprotective effects remain unclear. The present study investigated whether...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Fayin, Wang, Xiaodong, Zhang, Zhijie, Zhang, Xianlong, Gao, Pengfei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764501/ https://www.ncbi.nlm.nih.gov/pubmed/31478596 http://dx.doi.org/10.1002/acn3.50878

Ejemplares similares

Dexmedetomidine attenuates traumatic brain injury: action pathway and mechanisms
por: Wang, Dong, et al.
Publicado: (2018)

The role of bioactive lipids in attenuating the neuroinflammatory cascade in traumatic brain injury
por: Poblete, Roy A., et al.
Publicado: (2020)

Neuroinflammatory responses to traumatic brain injury
por: Paiva, Wellingson Silva, et al.
Publicado: (2015)

Dexmedetomidine alleviates early brain injury following traumatic brain injury by inhibiting autophagy and neuroinflammation through the ROS/Nrf2 signaling pathway
por: Feng, Xiaoyan, et al.
Publicado: (2021)

Dexmedetomidine Attenuates LPS-Induced Acute Lung Injury in Rats by Activating the Nrf2/ARE Pathway
por: Qiu, Yuandong, et al.
Publicado: (2022)

Acute Traumatic Brain Injury-Induced Neuroinflammatory Response and Neurovascular Disorders in the Brain
por: Kempuraj, Duraisamy, et al.
Publicado: (2020)

Ketamine ameliorates oxidative stress-induced apoptosis in experimental traumatic brain injury via the Nrf2 pathway
por: Liang, Jinwei, et al.
Publicado: (2018)

Neuroprotective effects of dexmedetomidine on traumatic brain injury: Involvement of neuronal apoptosis and HSP70 expression
por: Zhang, Man-He, et al.
Publicado: (2018)

Retracted: Dexmedetomidine Attenuates LPS-Induced Acute Lung Injury in Rats by Activating the Nrf2/ARE Pathway
por: Healthcare Engineering, Journal of
Publicado: (2023)

Fucoxanthin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE and Nrf2-autophagy pathways
por: Zhang, Li, et al.
Publicado: (2017)

Dexmedetomidine attenuates airway inflammation and oxidative stress in asthma via the Nrf2 signaling pathway
por: Xiao, Shilin, et al.
Publicado: (2022)

Sinomenine Provides Neuroprotection in Model of Traumatic Brain Injury via the Nrf2–ARE Pathway
por: Yang, Youqing, et al.
Publicado: (2016)

The Attenuation of Traumatic Brain Injury via Inhibition of Oxidative Stress and Apoptosis by Tanshinone IIA
por: Huang, Yongpan, et al.
Publicado: (2020)

Neuroinflammatory responses to traumatic brain injury: etiology, clinical consequences, and therapeutic opportunities
por: Lozano, Diego, et al.
Publicado: (2015)

Dexmedetomidine is neuroprotective in an in vitro model for traumatic brain injury
por: Schoeler, Marc, et al.
Publicado: (2012)

Valproic Acid Attenuates Traumatic Brain Injury-Induced Inflammation in Vivo: Involvement of Autophagy and the Nrf2/ARE Signaling Pathway
por: Chen, Xiangrong, et al.
Publicado: (2018)

Age exacerbates the CCR2/5-mediated neuroinflammatory response to traumatic brain injury
por: Morganti, Josh M., et al.
Publicado: (2016)

Differential fracture response to traumatic brain injury suggests dominance of neuroinflammatory response in polytrauma
por: Morioka, Kazuhito, et al.
Publicado: (2019)

Amorfrutins Relieve Neuropathic Pain through the PPARγ/CCL2 Axis in CCI Rats
por: Gao, Pengfei, et al.
Publicado: (2021)

Minocycline attenuates neuronal apoptosis and improves motor function after traumatic brain injury in rats
por: He, Jihong, et al.
Publicado: (2021)

Tim-3 deteriorates neuroinflammatory and neurocyte apoptosis after subarachnoid hemorrhage through the Nrf2/HMGB1 signaling pathway in rats
por: Guo, Shenquan, et al.
Publicado: (2020)

Comparison of dexmedetomidine and propofol for sedation in patients with traumatic brain injury
por: Tarabrin, O, et al.
Publicado: (2014)

Rutaecarpine Attenuates Oxidative Stress-Induced Traumatic Brain Injury and Reduces Secondary Injury via the PGK1/KEAP1/NRF2 Signaling Pathway
por: Xu, Min, et al.
Publicado: (2022)

Dexmedetomidine Protects Against Traumatic Brain Injury-Induced Acute Lung Injury in Mice
por: Wang, Yuanyuan, et al.
Publicado: (2018)

Dexmedetomidine Relieves Neuropathic Pain in Rats With Chronic Constriction Injury via the Keap1–Nrf2 Pathway
por: Liu, Yatao, et al.
Publicado: (2021)

Systemic inflammation alters the neuroinflammatory response: a prospective clinical trial in traumatic brain injury
por: Lassarén, Philipp, et al.
Publicado: (2021)

Neuroinflammatory Biomarkers for Traumatic Brain Injury Diagnosis and Prognosis: A TRACK-TBI Pilot Study
por: Yue, John K., et al.
Publicado: (2023)

Neuroprotection of NRF2 against Ferroptosis after Traumatic Brain Injury in Mice
por: Cheng, Hao, et al.
Publicado: (2023)

STING-mediated type-I interferons contribute to the neuroinflammatory process and detrimental effects following traumatic brain injury
por: Abdullah, Amar, et al.
Publicado: (2018)

Dexmedetomidine postconditioning attenuates myocardial ischemia/reperfusion injury by activating the Nrf2/Sirt3/SOD2 signaling pathway in the rats
por: Hu, Bin, et al.
Publicado: (2023)

Natural antioxidants for neuroinflammatory disorders and possible involvement of Nrf2 pathway: A review
por: Singh, Sanjiv, et al.
Publicado: (2021)

Neuroprotective effect of dexmedetomidine in a murine model of traumatic brain injury
por: Wu, Jin, et al.
Publicado: (2018)

Neuroinflammatory mechanisms of post-traumatic epilepsy
por: Mukherjee, Sanjib, et al.
Publicado: (2020)

Progesterone Provides the Pleiotropic Neuroprotective Effect on Traumatic Brain Injury Through the Nrf2/ARE Signaling Pathway
por: Zhang, Mei, et al.
Publicado: (2016)

Alpha lipoic acid inhibits oxidative stress‐induced apoptosis by modulating of Nrf2 signalling pathway after traumatic brain injury
por: Xia, Dayong, et al.
Publicado: (2019)

A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury
por: Kuwar, Ram, et al.
Publicado: (2019)

Protective Effects of Quercetin on Mitochondrial Biogenesis in Experimental Traumatic Brain Injury via the Nrf2 Signaling Pathway
por: Li, Xiang, et al.
Publicado: (2016)

Dexmedetomidine alleviates hepatic ischaemia‐reperfusion injury via the PI3K/AKT/Nrf2‐NLRP3 pathway
por: Wu, Yan, et al.
Publicado: (2021)

Intrathecal dexmedetomidine attenuates mechanical allodynia through the downregulation of brain-derived neurotrophic factor in a mild traumatic brain injury rat model
por: Jeon, Soeun, et al.
Publicado: (2023)

Monitoring the Neuroinflammatory Response Following Acute Brain Injury
por: Thelin, Eric Peter, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_nlr5aatsg13v2kj80qar6u88l2