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Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration
In neurodegenerative diseases, debris of dead neurons are thought to trigger glia-mediated neuroinflammation, thus increasing neuronal death. Here, we show that expression of neurotoxic proteins associated with these diseases in microglia alone is sufficient to trigger death of naïve neurons directl...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764589/ https://www.ncbi.nlm.nih.gov/pubmed/31551592 http://dx.doi.org/10.1038/s41593-019-0486-0 |