Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients

To search for discriminating biomarkers, 30 patients with idiopathic rapid‐eye‐movements sleep behavior disorder (iRBD) were compared with 17 patients with RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching for phosphorylated α‐synuclein depos...

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Autores principales: Antelmi, Elena, Pizza, Fabio, Donadio, Vincenzo, Filardi, Marco, Sosero, Yuri L., Incensi, Alex, Vandi, Stefano, Moresco, Monica, Ferri, Raffaele, Marelli, Sara, Ferini‐Strambi, Luigi, Liguori, Rocco, Plazzi, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764627/
https://www.ncbi.nlm.nih.gov/pubmed/31386270
http://dx.doi.org/10.1002/acn3.50833
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author Antelmi, Elena
Pizza, Fabio
Donadio, Vincenzo
Filardi, Marco
Sosero, Yuri L.
Incensi, Alex
Vandi, Stefano
Moresco, Monica
Ferri, Raffaele
Marelli, Sara
Ferini‐Strambi, Luigi
Liguori, Rocco
Plazzi, Giuseppe
author_facet Antelmi, Elena
Pizza, Fabio
Donadio, Vincenzo
Filardi, Marco
Sosero, Yuri L.
Incensi, Alex
Vandi, Stefano
Moresco, Monica
Ferri, Raffaele
Marelli, Sara
Ferini‐Strambi, Luigi
Liguori, Rocco
Plazzi, Giuseppe
author_sort Antelmi, Elena
collection PubMed
description To search for discriminating biomarkers, 30 patients with idiopathic rapid‐eye‐movements sleep behavior disorder (iRBD) were compared with 17 patients with RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching for phosphorylated α‐synuclein deposits and whole‐night video‐polysomnography. Skin biopsy was positive for phosphorylated α‐synuclein deposits in 86.7% of iRBD patients and in none of narcoleptic patients. The analysis of video‐polysomnographic motor events showed differences in their occurrence throughout the night in the two groups. iRBD and RBD due to narcolepsy do have different clinical and pathological findings, confirming a different pathophysiology.
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spelling pubmed-67646272019-09-30 Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients Antelmi, Elena Pizza, Fabio Donadio, Vincenzo Filardi, Marco Sosero, Yuri L. Incensi, Alex Vandi, Stefano Moresco, Monica Ferri, Raffaele Marelli, Sara Ferini‐Strambi, Luigi Liguori, Rocco Plazzi, Giuseppe Ann Clin Transl Neurol Brief Communications To search for discriminating biomarkers, 30 patients with idiopathic rapid‐eye‐movements sleep behavior disorder (iRBD) were compared with 17 patients with RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching for phosphorylated α‐synuclein deposits and whole‐night video‐polysomnography. Skin biopsy was positive for phosphorylated α‐synuclein deposits in 86.7% of iRBD patients and in none of narcoleptic patients. The analysis of video‐polysomnographic motor events showed differences in their occurrence throughout the night in the two groups. iRBD and RBD due to narcolepsy do have different clinical and pathological findings, confirming a different pathophysiology. John Wiley and Sons Inc. 2019-08-06 /pmc/articles/PMC6764627/ /pubmed/31386270 http://dx.doi.org/10.1002/acn3.50833 Text en © 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Communications
Antelmi, Elena
Pizza, Fabio
Donadio, Vincenzo
Filardi, Marco
Sosero, Yuri L.
Incensi, Alex
Vandi, Stefano
Moresco, Monica
Ferri, Raffaele
Marelli, Sara
Ferini‐Strambi, Luigi
Liguori, Rocco
Plazzi, Giuseppe
Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients
title Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients
title_full Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients
title_fullStr Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients
title_full_unstemmed Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients
title_short Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients
title_sort biomarkers for rem sleep behavior disorder in idiopathic and narcoleptic patients
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764627/
https://www.ncbi.nlm.nih.gov/pubmed/31386270
http://dx.doi.org/10.1002/acn3.50833
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