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Biomarkers predictive value for early diagnosis of Stroke‐Associated Pneumonia
To confirm the diagnostic accuracy of candidate biomarkers in stroke‐associated pneumonia (SAP), we prospectively enrolled ischemic stroke patients with NIHSS ≥ 10 on admission from March‐2016 to August‐2017. Blood samples were collected at baseline, 24 and 48 h after stroke onset. Biomarkers (MR‐pr...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764629/ https://www.ncbi.nlm.nih.gov/pubmed/31365180 http://dx.doi.org/10.1002/acn3.50849 |
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author | Zapata‐Arriaza, Elena Mancha, Fernando Bustamante, Alejandro Moniche, Francisco Pardo‐Galiana, Blanca Serrano‐Gotarredona, Pilar Navarro‐Herrero, Silvia Pallisa, Esther Faura, Julia Vega‐Salvatierra, Ángela Penalba, Anna Escudero‐Martínez, Irene Ramos‐Herrero, Víctor Darío Azurmendi, Leire Charles Sanchez, Jean Montaner, Joan |
author_facet | Zapata‐Arriaza, Elena Mancha, Fernando Bustamante, Alejandro Moniche, Francisco Pardo‐Galiana, Blanca Serrano‐Gotarredona, Pilar Navarro‐Herrero, Silvia Pallisa, Esther Faura, Julia Vega‐Salvatierra, Ángela Penalba, Anna Escudero‐Martínez, Irene Ramos‐Herrero, Víctor Darío Azurmendi, Leire Charles Sanchez, Jean Montaner, Joan |
author_sort | Zapata‐Arriaza, Elena |
collection | PubMed |
description | To confirm the diagnostic accuracy of candidate biomarkers in stroke‐associated pneumonia (SAP), we prospectively enrolled ischemic stroke patients with NIHSS ≥ 10 on admission from March‐2016 to August‐2017. Blood samples were collected at baseline, 24 and 48 h after stroke onset. Biomarkers (MR‐proADM, suPAR, SAA) were determined by immunoassays. Regarding biomarkers, MR‐proADM at 24 h (P = 0.04) and both suPAR and SAA at 48 h (P = 0.036 and P = 0.057) were associated with pneumonia. The combination of SAA > 25.15 mg/dL and suPAR> 3.14 ng/mL at 48 h had 80% sensitivity and 95.8% specificity when both biomarkers were above the cut‐off. The evaluated biomarkers represent promising tools to be evaluated in future large, prospective studies on SAP. An accurate SAP diagnosis by thorax CT might help to reduce variability in such studies. |
format | Online Article Text |
id | pubmed-6764629 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67646292019-09-30 Biomarkers predictive value for early diagnosis of Stroke‐Associated Pneumonia Zapata‐Arriaza, Elena Mancha, Fernando Bustamante, Alejandro Moniche, Francisco Pardo‐Galiana, Blanca Serrano‐Gotarredona, Pilar Navarro‐Herrero, Silvia Pallisa, Esther Faura, Julia Vega‐Salvatierra, Ángela Penalba, Anna Escudero‐Martínez, Irene Ramos‐Herrero, Víctor Darío Azurmendi, Leire Charles Sanchez, Jean Montaner, Joan Ann Clin Transl Neurol Brief Communications To confirm the diagnostic accuracy of candidate biomarkers in stroke‐associated pneumonia (SAP), we prospectively enrolled ischemic stroke patients with NIHSS ≥ 10 on admission from March‐2016 to August‐2017. Blood samples were collected at baseline, 24 and 48 h after stroke onset. Biomarkers (MR‐proADM, suPAR, SAA) were determined by immunoassays. Regarding biomarkers, MR‐proADM at 24 h (P = 0.04) and both suPAR and SAA at 48 h (P = 0.036 and P = 0.057) were associated with pneumonia. The combination of SAA > 25.15 mg/dL and suPAR> 3.14 ng/mL at 48 h had 80% sensitivity and 95.8% specificity when both biomarkers were above the cut‐off. The evaluated biomarkers represent promising tools to be evaluated in future large, prospective studies on SAP. An accurate SAP diagnosis by thorax CT might help to reduce variability in such studies. John Wiley and Sons Inc. 2019-07-31 /pmc/articles/PMC6764629/ /pubmed/31365180 http://dx.doi.org/10.1002/acn3.50849 Text en © 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Brief Communications Zapata‐Arriaza, Elena Mancha, Fernando Bustamante, Alejandro Moniche, Francisco Pardo‐Galiana, Blanca Serrano‐Gotarredona, Pilar Navarro‐Herrero, Silvia Pallisa, Esther Faura, Julia Vega‐Salvatierra, Ángela Penalba, Anna Escudero‐Martínez, Irene Ramos‐Herrero, Víctor Darío Azurmendi, Leire Charles Sanchez, Jean Montaner, Joan Biomarkers predictive value for early diagnosis of Stroke‐Associated Pneumonia |
title | Biomarkers predictive value for early diagnosis of Stroke‐Associated Pneumonia |
title_full | Biomarkers predictive value for early diagnosis of Stroke‐Associated Pneumonia |
title_fullStr | Biomarkers predictive value for early diagnosis of Stroke‐Associated Pneumonia |
title_full_unstemmed | Biomarkers predictive value for early diagnosis of Stroke‐Associated Pneumonia |
title_short | Biomarkers predictive value for early diagnosis of Stroke‐Associated Pneumonia |
title_sort | biomarkers predictive value for early diagnosis of stroke‐associated pneumonia |
topic | Brief Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764629/ https://www.ncbi.nlm.nih.gov/pubmed/31365180 http://dx.doi.org/10.1002/acn3.50849 |
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