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Pregnancy does not adversely impact diagnostic tests for HTLV-1/2 infection

Mother-to-child-transmission (MTCT) of human T-cell lymphotropic virus type-1(HTLV-1) contributes disproportionately to the burden of HTLV-1 associated diseases. All preventive measures to avoid MTCT rely on the identification of infected mothers. However, the impact of pregnancy on HTLV-1 diagnosis...

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Detalles Bibliográficos
Autores principales: Rosadas, Carolina, Tosswill, Jennifer H., Tedder, Richard, Taylor, Graham P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764679/
https://www.ncbi.nlm.nih.gov/pubmed/31513603
http://dx.doi.org/10.1371/journal.pntd.0007736
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author Rosadas, Carolina
Tosswill, Jennifer H.
Tedder, Richard
Taylor, Graham P.
author_facet Rosadas, Carolina
Tosswill, Jennifer H.
Tedder, Richard
Taylor, Graham P.
author_sort Rosadas, Carolina
collection PubMed
description Mother-to-child-transmission (MTCT) of human T-cell lymphotropic virus type-1(HTLV-1) contributes disproportionately to the burden of HTLV-1 associated diseases. All preventive measures to avoid MTCT rely on the identification of infected mothers. However, the impact of pregnancy on HTLV-1 diagnosis has not been clearly assessed. Paired samples from 21 HTLV-1 infected women taken during pregnancy and while not pregnant were analysed by CMIA and PCR. The signal-to-cut-off values (S/CO) were higher during pregnancy than in the paired non-pregnant samples. HTLV-1 proviral load did not alter significantly by pregnant state. S/CO positively correlated with HTLV proviral load. Pregnancy does not impair the diagnosis of HTLV-1/2, by either immunological (CMIA) or molecular (qPCR/nPCR) tests.
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spelling pubmed-67646792019-10-11 Pregnancy does not adversely impact diagnostic tests for HTLV-1/2 infection Rosadas, Carolina Tosswill, Jennifer H. Tedder, Richard Taylor, Graham P. PLoS Negl Trop Dis Research Article Mother-to-child-transmission (MTCT) of human T-cell lymphotropic virus type-1(HTLV-1) contributes disproportionately to the burden of HTLV-1 associated diseases. All preventive measures to avoid MTCT rely on the identification of infected mothers. However, the impact of pregnancy on HTLV-1 diagnosis has not been clearly assessed. Paired samples from 21 HTLV-1 infected women taken during pregnancy and while not pregnant were analysed by CMIA and PCR. The signal-to-cut-off values (S/CO) were higher during pregnancy than in the paired non-pregnant samples. HTLV-1 proviral load did not alter significantly by pregnant state. S/CO positively correlated with HTLV proviral load. Pregnancy does not impair the diagnosis of HTLV-1/2, by either immunological (CMIA) or molecular (qPCR/nPCR) tests. Public Library of Science 2019-09-12 /pmc/articles/PMC6764679/ /pubmed/31513603 http://dx.doi.org/10.1371/journal.pntd.0007736 Text en © 2019 Rosadas et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Rosadas, Carolina
Tosswill, Jennifer H.
Tedder, Richard
Taylor, Graham P.
Pregnancy does not adversely impact diagnostic tests for HTLV-1/2 infection
title Pregnancy does not adversely impact diagnostic tests for HTLV-1/2 infection
title_full Pregnancy does not adversely impact diagnostic tests for HTLV-1/2 infection
title_fullStr Pregnancy does not adversely impact diagnostic tests for HTLV-1/2 infection
title_full_unstemmed Pregnancy does not adversely impact diagnostic tests for HTLV-1/2 infection
title_short Pregnancy does not adversely impact diagnostic tests for HTLV-1/2 infection
title_sort pregnancy does not adversely impact diagnostic tests for htlv-1/2 infection
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764679/
https://www.ncbi.nlm.nih.gov/pubmed/31513603
http://dx.doi.org/10.1371/journal.pntd.0007736
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