Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies

The CD4 binding site (CD4bs) of the HIV-1 envelope glycoprotein is susceptible to multiple lineages of broadly neutralizing antibodies (bnAbs) that are attractive to elicit with vaccines. The CH235 lineage (VH1-46) of CD4bs bnAbs is particularly attractive because the most mature members neutralize...

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Detalles Bibliográficos
Autores principales: LaBranche, Celia C., Henderson, Rory, Hsu, Allen, Behrens, Shay, Chen, Xuejun, Zhou, Tongqing, Wiehe, Kevin, Saunders, Kevin O., Alam, S. Munir, Bonsignori, Mattia, Borgnia, Mario J., Sattentau, Quentin J., Eaton, Amanda, Greene, Kelli, Gao, Hongmei, Liao, Hua-Xin, Williams, Wilton B., Peacock, James, Tang, Haili, Perez, Lautaro G., Edwards, Robert J., Kepler, Thomas B., Korber, Bette T., Kwong, Peter D., Mascola, John R., Acharya, Priyamvada, Haynes, Barton F., Montefiori, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764681/
https://www.ncbi.nlm.nih.gov/pubmed/31527908
http://dx.doi.org/10.1371/journal.ppat.1008026

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