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Characteristics of proximal early gastric cancer differentiating distal early gastric cancer

Previous studies reported substantial differences between proximal and distal gastric cancer, however, most of the cases included in these studies were advanced gastric cancers (AGCs). The aim of this study was to investigate the unique characteristics of proximal early gastric cancer (EGC) by compa...

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Autores principales: Koh, Jin Sung, Joo, Moon Kyung, Park, Jong-Jae, Lee, Beom Jae, Chun, Hoon Jai, Lee, Sang Woo, Jang, You-Jin, Mok, Young-Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764682/
https://www.ncbi.nlm.nih.gov/pubmed/31560720
http://dx.doi.org/10.1371/journal.pone.0223284
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author Koh, Jin Sung
Joo, Moon Kyung
Park, Jong-Jae
Lee, Beom Jae
Chun, Hoon Jai
Lee, Sang Woo
Jang, You-Jin
Mok, Young-Jae
author_facet Koh, Jin Sung
Joo, Moon Kyung
Park, Jong-Jae
Lee, Beom Jae
Chun, Hoon Jai
Lee, Sang Woo
Jang, You-Jin
Mok, Young-Jae
author_sort Koh, Jin Sung
collection PubMed
description Previous studies reported substantial differences between proximal and distal gastric cancer, however, most of the cases included in these studies were advanced gastric cancers (AGCs). The aim of this study was to investigate the unique characteristics of proximal early gastric cancer (EGC) by comparing with distal EGC. From March 2007 to March 2016, proximal and distal EGC patients who underwent endoscopic or surgical resection at our institution were matched 1:3 according to age and sex. We retrospectively analyzed the clinical and histopathological information. A total of 368 patients were enrolled including 92 (25%) in the proximal and 276 (75%) in the distal group. The proportion of patients who underwent surgery (56.5 vs. 20.3%, p<0.001), undifferentiated type (38.0 vs. 19.6%, p<0.001), tumor size (29.5 ±19.4 vs. 20.3 ±16.8 mm, p<0.001) and submucosal (SM) invasion (60.9 vs. 25.7%, p<0.001) were significantly higher in the proximal group than in the distal group. In multivariate analysis, the proximal location of EGC was a significant risk factor for SM invasion in the total population (odds ratio [OR], 3.541; 95% confidence interval [CI], 2.053–6.110; p<0.001), and in subgroup with EGC < 30mm (n = 279) (OR, 5.940; 95% CI, 2.974–11.862; p<0.001). In conclusion, careful therapeutic decision of proximal EGC is essential due to the different histopathological characteristics such as large tumor size and higher potential for SM invasion.
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spelling pubmed-67646822019-10-12 Characteristics of proximal early gastric cancer differentiating distal early gastric cancer Koh, Jin Sung Joo, Moon Kyung Park, Jong-Jae Lee, Beom Jae Chun, Hoon Jai Lee, Sang Woo Jang, You-Jin Mok, Young-Jae PLoS One Research Article Previous studies reported substantial differences between proximal and distal gastric cancer, however, most of the cases included in these studies were advanced gastric cancers (AGCs). The aim of this study was to investigate the unique characteristics of proximal early gastric cancer (EGC) by comparing with distal EGC. From March 2007 to March 2016, proximal and distal EGC patients who underwent endoscopic or surgical resection at our institution were matched 1:3 according to age and sex. We retrospectively analyzed the clinical and histopathological information. A total of 368 patients were enrolled including 92 (25%) in the proximal and 276 (75%) in the distal group. The proportion of patients who underwent surgery (56.5 vs. 20.3%, p<0.001), undifferentiated type (38.0 vs. 19.6%, p<0.001), tumor size (29.5 ±19.4 vs. 20.3 ±16.8 mm, p<0.001) and submucosal (SM) invasion (60.9 vs. 25.7%, p<0.001) were significantly higher in the proximal group than in the distal group. In multivariate analysis, the proximal location of EGC was a significant risk factor for SM invasion in the total population (odds ratio [OR], 3.541; 95% confidence interval [CI], 2.053–6.110; p<0.001), and in subgroup with EGC < 30mm (n = 279) (OR, 5.940; 95% CI, 2.974–11.862; p<0.001). In conclusion, careful therapeutic decision of proximal EGC is essential due to the different histopathological characteristics such as large tumor size and higher potential for SM invasion. Public Library of Science 2019-09-27 /pmc/articles/PMC6764682/ /pubmed/31560720 http://dx.doi.org/10.1371/journal.pone.0223284 Text en © 2019 Koh et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Koh, Jin Sung
Joo, Moon Kyung
Park, Jong-Jae
Lee, Beom Jae
Chun, Hoon Jai
Lee, Sang Woo
Jang, You-Jin
Mok, Young-Jae
Characteristics of proximal early gastric cancer differentiating distal early gastric cancer
title Characteristics of proximal early gastric cancer differentiating distal early gastric cancer
title_full Characteristics of proximal early gastric cancer differentiating distal early gastric cancer
title_fullStr Characteristics of proximal early gastric cancer differentiating distal early gastric cancer
title_full_unstemmed Characteristics of proximal early gastric cancer differentiating distal early gastric cancer
title_short Characteristics of proximal early gastric cancer differentiating distal early gastric cancer
title_sort characteristics of proximal early gastric cancer differentiating distal early gastric cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764682/
https://www.ncbi.nlm.nih.gov/pubmed/31560720
http://dx.doi.org/10.1371/journal.pone.0223284
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