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Characteristics of proximal early gastric cancer differentiating distal early gastric cancer
Previous studies reported substantial differences between proximal and distal gastric cancer, however, most of the cases included in these studies were advanced gastric cancers (AGCs). The aim of this study was to investigate the unique characteristics of proximal early gastric cancer (EGC) by compa...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764682/ https://www.ncbi.nlm.nih.gov/pubmed/31560720 http://dx.doi.org/10.1371/journal.pone.0223284 |
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author | Koh, Jin Sung Joo, Moon Kyung Park, Jong-Jae Lee, Beom Jae Chun, Hoon Jai Lee, Sang Woo Jang, You-Jin Mok, Young-Jae |
author_facet | Koh, Jin Sung Joo, Moon Kyung Park, Jong-Jae Lee, Beom Jae Chun, Hoon Jai Lee, Sang Woo Jang, You-Jin Mok, Young-Jae |
author_sort | Koh, Jin Sung |
collection | PubMed |
description | Previous studies reported substantial differences between proximal and distal gastric cancer, however, most of the cases included in these studies were advanced gastric cancers (AGCs). The aim of this study was to investigate the unique characteristics of proximal early gastric cancer (EGC) by comparing with distal EGC. From March 2007 to March 2016, proximal and distal EGC patients who underwent endoscopic or surgical resection at our institution were matched 1:3 according to age and sex. We retrospectively analyzed the clinical and histopathological information. A total of 368 patients were enrolled including 92 (25%) in the proximal and 276 (75%) in the distal group. The proportion of patients who underwent surgery (56.5 vs. 20.3%, p<0.001), undifferentiated type (38.0 vs. 19.6%, p<0.001), tumor size (29.5 ±19.4 vs. 20.3 ±16.8 mm, p<0.001) and submucosal (SM) invasion (60.9 vs. 25.7%, p<0.001) were significantly higher in the proximal group than in the distal group. In multivariate analysis, the proximal location of EGC was a significant risk factor for SM invasion in the total population (odds ratio [OR], 3.541; 95% confidence interval [CI], 2.053–6.110; p<0.001), and in subgroup with EGC < 30mm (n = 279) (OR, 5.940; 95% CI, 2.974–11.862; p<0.001). In conclusion, careful therapeutic decision of proximal EGC is essential due to the different histopathological characteristics such as large tumor size and higher potential for SM invasion. |
format | Online Article Text |
id | pubmed-6764682 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-67646822019-10-12 Characteristics of proximal early gastric cancer differentiating distal early gastric cancer Koh, Jin Sung Joo, Moon Kyung Park, Jong-Jae Lee, Beom Jae Chun, Hoon Jai Lee, Sang Woo Jang, You-Jin Mok, Young-Jae PLoS One Research Article Previous studies reported substantial differences between proximal and distal gastric cancer, however, most of the cases included in these studies were advanced gastric cancers (AGCs). The aim of this study was to investigate the unique characteristics of proximal early gastric cancer (EGC) by comparing with distal EGC. From March 2007 to March 2016, proximal and distal EGC patients who underwent endoscopic or surgical resection at our institution were matched 1:3 according to age and sex. We retrospectively analyzed the clinical and histopathological information. A total of 368 patients were enrolled including 92 (25%) in the proximal and 276 (75%) in the distal group. The proportion of patients who underwent surgery (56.5 vs. 20.3%, p<0.001), undifferentiated type (38.0 vs. 19.6%, p<0.001), tumor size (29.5 ±19.4 vs. 20.3 ±16.8 mm, p<0.001) and submucosal (SM) invasion (60.9 vs. 25.7%, p<0.001) were significantly higher in the proximal group than in the distal group. In multivariate analysis, the proximal location of EGC was a significant risk factor for SM invasion in the total population (odds ratio [OR], 3.541; 95% confidence interval [CI], 2.053–6.110; p<0.001), and in subgroup with EGC < 30mm (n = 279) (OR, 5.940; 95% CI, 2.974–11.862; p<0.001). In conclusion, careful therapeutic decision of proximal EGC is essential due to the different histopathological characteristics such as large tumor size and higher potential for SM invasion. Public Library of Science 2019-09-27 /pmc/articles/PMC6764682/ /pubmed/31560720 http://dx.doi.org/10.1371/journal.pone.0223284 Text en © 2019 Koh et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Koh, Jin Sung Joo, Moon Kyung Park, Jong-Jae Lee, Beom Jae Chun, Hoon Jai Lee, Sang Woo Jang, You-Jin Mok, Young-Jae Characteristics of proximal early gastric cancer differentiating distal early gastric cancer |
title | Characteristics of proximal early gastric cancer differentiating distal early gastric cancer |
title_full | Characteristics of proximal early gastric cancer differentiating distal early gastric cancer |
title_fullStr | Characteristics of proximal early gastric cancer differentiating distal early gastric cancer |
title_full_unstemmed | Characteristics of proximal early gastric cancer differentiating distal early gastric cancer |
title_short | Characteristics of proximal early gastric cancer differentiating distal early gastric cancer |
title_sort | characteristics of proximal early gastric cancer differentiating distal early gastric cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764682/ https://www.ncbi.nlm.nih.gov/pubmed/31560720 http://dx.doi.org/10.1371/journal.pone.0223284 |
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