Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/β-Catenin

Indian Hedgehog (IHH) signaling, a key regulator of skeletal development, is highly activated in cartilage and bone tumors. Yet deletion of Ptch1, encoding an inhibitor of IHH receptor Smoothened (SMO), in chondrocyte or osteoblasts does not cause tumorigenesis. Here, we show that Ptch1 deletion in...

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Detalles Bibliográficos
Autores principales: Deng, Qi, Li, Ping, Che, Manju, Liu, Jiajia, Biswas, Soma, Ma, Gang, He, Lin, Wei, Zhanying, Zhang, Zhenlin, Yang, Yingzi, Liu, Huijuan, Li, Baojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764825/
https://www.ncbi.nlm.nih.gov/pubmed/31482846
http://dx.doi.org/10.7554/eLife.50208

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