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ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis

Cystic Fibrosis (CF) is a monogenic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, resulting in defective CFTR-mediated chloride and bicarbonate transport, with dysregulation of epithelial sodium channels (ENaC). These changes alter fluid and elec...

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Detalles Bibliográficos
Autores principales:	Scambler, Thomas, Jarosz-Griffiths, Heledd H, Lara-Reyna, Samuel, Pathak, Shelly, Wong, Chi, Holbrook, Jonathan, Martinon, Fabio, Savic, Sinisa, Peckham, Daniel, McDermott, Michael F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Human Biology and Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764826/ https://www.ncbi.nlm.nih.gov/pubmed/31532390 http://dx.doi.org/10.7554/eLife.49248

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