PKN1 kinase-negative knock-in mice develop splenomegaly and leukopenia at advanced age without obvious autoimmune-like phenotypes

Protein kinase N1 (PKN1) knockout (KO) mice spontaneously form germinal centers (GCs) and develop an autoimmune-like disease with age. Here, we investigated the function of PKN1 kinase activity in vivo using aged mice deficient in kinase activity resulting from the introduction of a point mutation (...

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Detalles Bibliográficos
Autores principales: Siddique, Salman Mahmud, Kubouchi, Koji, Shinmichi, Yuka, Sawada, Nana, Sugiura, Reiko, Itoh, Yasushi, Uehara, Shunsuke, Nishimura, Kanae, Okamura, Shunsuke, Ohsaki, Hiroyuki, Kamoshida, Shingo, Yamashita, Yusuke, Tamura, Shinobu, Sonoki, Takashi, Matsuoka, Hiroshi, Itoh, Tomoo, Mukai, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764976/
https://www.ncbi.nlm.nih.gov/pubmed/31562379
http://dx.doi.org/10.1038/s41598-019-50419-2

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