Tissue-engineered blood-brain barrier models via directed differentiation of human induced pluripotent stem cells

Three-dimensional (3D) tissue-engineered models of the blood-brain barrier (BBB) recapitulate in vivo shear stress, cylindrical geometry, and cell-ECM interactions. Here we address four issues associated with BBB models: cell source, barrier function, cryopreservation, and matrix stiffness. We repro...

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Detalles Bibliográficos
Autores principales: Grifno, Gabrielle N., Farrell, Alanna M., Linville, Raleigh M., Arevalo, Diego, Kim, Joo Ho, Gu, Luo, Searson, Peter C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764995/
https://www.ncbi.nlm.nih.gov/pubmed/31562392
http://dx.doi.org/10.1038/s41598-019-50193-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764995/
https://www.ncbi.nlm.nih.gov/pubmed/31562392
http://dx.doi.org/10.1038/s41598-019-50193-1

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