Human immunoglobulin G hinge regulates agonistic anti-CD40 immunostimulatory and antitumour activities through biophysical flexibility

Human immunoglobulin G (IgG) agonistic antibodies targeting costimulatory immunoreceptors represent promising cancer immunotherapies yet to be developed. Whether, and how, human IgG hinge and Fc impact on their agonistic functions have been disputed. Here, we show that different natural human IgGs c...

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Detalles Bibliográficos
Autores principales: Liu, Xiaobo, Zhao, Yingjie, Shi, Huan, Zhang, Yan, Yin, Xueying, Liu, Mingdong, Zhang, Huihui, He, Yongning, Lu, Boxun, Jin, Tengchuan, Li, Fubin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765011/
https://www.ncbi.nlm.nih.gov/pubmed/31562320
http://dx.doi.org/10.1038/s41467-019-12097-6

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