Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes

Insulin and IGF-1 actions in vascular smooth muscle cells (VSMC) are associated with accelerated arterial intima hyperplasia and restenosis after angioplasty, especially in diabetes. To distinguish their relative roles, we delete insulin receptor (SMIRKO) or IGF-1 receptor (SMIGF1RKO) in VSMC and in...

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Detalles Bibliográficos
Autores principales: Li, Qian, Fu, Jialin, Xia, Yu, Qi, Weier, Ishikado, Atsushi, Park, Kyoungmin, Yokomizo, Hisashi, Huang, Qian, Cai, Weikang, Rask-Madsen, Christian, Kahn, C. Ronald, King, George L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765023/
https://www.ncbi.nlm.nih.gov/pubmed/31562314
http://dx.doi.org/10.1038/s41467-019-12368-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765023/
https://www.ncbi.nlm.nih.gov/pubmed/31562314
http://dx.doi.org/10.1038/s41467-019-12368-2

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