Therapeutic targeting of Notch signaling and immune checkpoint blockade in a spontaneous, genetically heterogeneous mouse model of T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic cancer derived from the malignant transformation of T-cell progenitors. Outcomes remain poor for T-ALL patients who have either primary resistance to standard-of-care chemotherapy or disease relapse. Notably, there are currentl...

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Detalles Bibliográficos
Autores principales: Gao, Jie, Van Meter, Michael, Hernandez Lopez, Susana, Chen, Guoying, Huang, Ying, Ren, Shumei, Zhao, Qi, Rojas, Jose, Gurer, Cagan, Thurston, Gavin, Kuhnert, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765191/
https://www.ncbi.nlm.nih.gov/pubmed/31399482
http://dx.doi.org/10.1242/dmm.040931

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