Neurokinin-1 receptor is an effective target for treating leukemia by inducing oxidative stress through mitochondrial calcium overload

Substance P (SP) regulates multiple biological processes through its high-affinity neurokinin-1 receptor (NK-1R). While the SP/NK-1R signaling axis is involved in the pathogenesis of solid cancer, the role of this signaling pathway in hematological malignancy remains unknown. Here, we demonstrate th...

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Detalles Bibliográficos
Autores principales: Ge, Chentao, Huang, Hemiao, Huang, Feiyan, Yang, Tianxin, Zhang, Tengfei, Wu, Hongzhang, Zhou, Hanwei, Chen, Qi, Shi, Yue, Sun, Yanfang, Liu, Liangjue, Wang, Xi, Pearson, Richard B., Cao, Yihai, Kang, Jian, Fu, Caiyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765257/
https://www.ncbi.nlm.nih.gov/pubmed/31488714
http://dx.doi.org/10.1073/pnas.1908998116

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