Cargando…
Chronic Fluoride Exposure and the Risk of Autism Spectrum Disorder
The continuous rise of autism spectrum disorder (ASD) prevalent in the past few decades is causing an increase in public health and socioeconomic concern. A consensus suggests the involvement of both genetic and environmental factors in the ASD etiopathogenesis. Fluoride (F) is rarely recognized amo...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765894/ https://www.ncbi.nlm.nih.gov/pubmed/31527457 http://dx.doi.org/10.3390/ijerph16183431 |
_version_ | 1783454589657284608 |
---|---|
author | Strunecka, Anna Strunecky, Otakar |
author_facet | Strunecka, Anna Strunecky, Otakar |
author_sort | Strunecka, Anna |
collection | PubMed |
description | The continuous rise of autism spectrum disorder (ASD) prevalent in the past few decades is causing an increase in public health and socioeconomic concern. A consensus suggests the involvement of both genetic and environmental factors in the ASD etiopathogenesis. Fluoride (F) is rarely recognized among the environmental risk factors of ASD, since the neurotoxic effects of F are not generally accepted. Our review aims to provide evidence of F neurotoxicity. We assess the risk of chronic F exposure in the ASD etiopathology and investigate the role of metabolic and mitochondrial dysfunction, oxidative stress and inflammation, immunoexcitotoxicity, and decreased melatonin levels. These symptoms have been observed both after chronic F exposure as well as in ASD. Moreover, we show that F in synergistic interactions with aluminum’s free metal cation (Al(3+)) can reinforce the pathological symptoms of ASD. This reinforcement takes place at concentrations several times lower than when acting alone. A high ASD prevalence has been reported from countries with water fluoridation as well as from endemic fluorosis areas. We suggest focusing the ASD prevention on the reduction of the F and Al(3+) burdens from daily life. |
format | Online Article Text |
id | pubmed-6765894 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67658942019-09-30 Chronic Fluoride Exposure and the Risk of Autism Spectrum Disorder Strunecka, Anna Strunecky, Otakar Int J Environ Res Public Health Review The continuous rise of autism spectrum disorder (ASD) prevalent in the past few decades is causing an increase in public health and socioeconomic concern. A consensus suggests the involvement of both genetic and environmental factors in the ASD etiopathogenesis. Fluoride (F) is rarely recognized among the environmental risk factors of ASD, since the neurotoxic effects of F are not generally accepted. Our review aims to provide evidence of F neurotoxicity. We assess the risk of chronic F exposure in the ASD etiopathology and investigate the role of metabolic and mitochondrial dysfunction, oxidative stress and inflammation, immunoexcitotoxicity, and decreased melatonin levels. These symptoms have been observed both after chronic F exposure as well as in ASD. Moreover, we show that F in synergistic interactions with aluminum’s free metal cation (Al(3+)) can reinforce the pathological symptoms of ASD. This reinforcement takes place at concentrations several times lower than when acting alone. A high ASD prevalence has been reported from countries with water fluoridation as well as from endemic fluorosis areas. We suggest focusing the ASD prevention on the reduction of the F and Al(3+) burdens from daily life. MDPI 2019-09-16 2019-09 /pmc/articles/PMC6765894/ /pubmed/31527457 http://dx.doi.org/10.3390/ijerph16183431 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Strunecka, Anna Strunecky, Otakar Chronic Fluoride Exposure and the Risk of Autism Spectrum Disorder |
title | Chronic Fluoride Exposure and the Risk of Autism Spectrum Disorder |
title_full | Chronic Fluoride Exposure and the Risk of Autism Spectrum Disorder |
title_fullStr | Chronic Fluoride Exposure and the Risk of Autism Spectrum Disorder |
title_full_unstemmed | Chronic Fluoride Exposure and the Risk of Autism Spectrum Disorder |
title_short | Chronic Fluoride Exposure and the Risk of Autism Spectrum Disorder |
title_sort | chronic fluoride exposure and the risk of autism spectrum disorder |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765894/ https://www.ncbi.nlm.nih.gov/pubmed/31527457 http://dx.doi.org/10.3390/ijerph16183431 |
work_keys_str_mv | AT struneckaanna chronicfluorideexposureandtheriskofautismspectrumdisorder AT struneckyotakar chronicfluorideexposureandtheriskofautismspectrumdisorder |