Cargando…

Therapeutic Opportunities in Colorectal Cancer: Focus on Melatonin Antioncogenic Action

Colorectal cancer (CRC) influences individual health worldwide with high morbidity and mortality. Melatonin, which shows multiple physiological functions (e.g., circadian rhythm, immune modulation, and antioncogenic action), can be present in almost all organisms and found in various tissues includi...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Hucong, Liu, Jiaqi, Yin, Yi, Zhang, Dong, Xia, Pengpeng, Zhu, Guoqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766109/
https://www.ncbi.nlm.nih.gov/pubmed/31637261
http://dx.doi.org/10.1155/2019/9740568
Descripción
Sumario:Colorectal cancer (CRC) influences individual health worldwide with high morbidity and mortality. Melatonin, which shows multiple physiological functions (e.g., circadian rhythm, immune modulation, and antioncogenic action), can be present in almost all organisms and found in various tissues including gastrointestinal tract. Notably, melatonin disruption is closely associated with the elevation of CRC incidence, indicating that melatonin is effective in suppressing CRC development and progression. Mechanistically, melatonin favors in activating apoptosis and colon cancer immunity, while reducing proliferation, autophagy, metastasis, and angiogenesis, thereby exerting its anticarcinogenic effects. This review highlights that melatonin can be an adjuvant therapy and be beneficial in treating patients suffering from CRC.