Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels

Ferroptosis is an iron-dependent type of cell death distinct from apoptosis or necrosis characterized by accumulation of reactive oxygen species. The combination of siramesine, a lysosomotropic agent, and lapatinib, a dual tyrosine kinase inhibitor (TKI), synergistically induced cell death in breast...

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Detalles Bibliográficos
Autores principales: Villalpando-Rodriguez, Gloria E., Blankstein, Anna R., Konzelman, Carmen, Gibson, Spencer B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766165/
https://www.ncbi.nlm.nih.gov/pubmed/31636810
http://dx.doi.org/10.1155/2019/9561281

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