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Flexible Polycaprolactone and Polycaprolactone/Graphene Scaffolds for Tissue Engineering

Developing bone scaffolds can greatly improve the patient’s quality of life by accelerating the rehabilitation process. In this paper, we studied the process of composite polycaprolactone supercritical foaming for tissue engineering. The influence of graphene oxide and reduced graphene oxide on the...

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Autores principales: Evlashin, Stanislav, Dyakonov, Pavel, Tarkhov, Mikhail, Dagesyan, Sarkis, Rodionov, Sergey, Shpichka, Anastasia, Kostenko, Mikhail, Konev, Stepan, Sergeichev, Ivan, Timashev, Petr, Akhatov, Iskander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766362/
https://www.ncbi.nlm.nih.gov/pubmed/31527398
http://dx.doi.org/10.3390/ma12182991
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author Evlashin, Stanislav
Dyakonov, Pavel
Tarkhov, Mikhail
Dagesyan, Sarkis
Rodionov, Sergey
Shpichka, Anastasia
Kostenko, Mikhail
Konev, Stepan
Sergeichev, Ivan
Timashev, Petr
Akhatov, Iskander
author_facet Evlashin, Stanislav
Dyakonov, Pavel
Tarkhov, Mikhail
Dagesyan, Sarkis
Rodionov, Sergey
Shpichka, Anastasia
Kostenko, Mikhail
Konev, Stepan
Sergeichev, Ivan
Timashev, Petr
Akhatov, Iskander
author_sort Evlashin, Stanislav
collection PubMed
description Developing bone scaffolds can greatly improve the patient’s quality of life by accelerating the rehabilitation process. In this paper, we studied the process of composite polycaprolactone supercritical foaming for tissue engineering. The influence of graphene oxide and reduced graphene oxide on the foaming parameters was studied. The structural and mechanical properties were studied. The scaffolds demonstrated mechanical flexibility and endurance. The co-culturing and live/dead tests demonstrated that the obtained scaffolds are biocompatible. Different composite scaffolds induced various surface cell behaviors. The experimental data demonstrate that composite foams are promising candidates for in vivo medical trials.
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spelling pubmed-67663622019-09-30 Flexible Polycaprolactone and Polycaprolactone/Graphene Scaffolds for Tissue Engineering Evlashin, Stanislav Dyakonov, Pavel Tarkhov, Mikhail Dagesyan, Sarkis Rodionov, Sergey Shpichka, Anastasia Kostenko, Mikhail Konev, Stepan Sergeichev, Ivan Timashev, Petr Akhatov, Iskander Materials (Basel) Article Developing bone scaffolds can greatly improve the patient’s quality of life by accelerating the rehabilitation process. In this paper, we studied the process of composite polycaprolactone supercritical foaming for tissue engineering. The influence of graphene oxide and reduced graphene oxide on the foaming parameters was studied. The structural and mechanical properties were studied. The scaffolds demonstrated mechanical flexibility and endurance. The co-culturing and live/dead tests demonstrated that the obtained scaffolds are biocompatible. Different composite scaffolds induced various surface cell behaviors. The experimental data demonstrate that composite foams are promising candidates for in vivo medical trials. MDPI 2019-09-16 /pmc/articles/PMC6766362/ /pubmed/31527398 http://dx.doi.org/10.3390/ma12182991 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Evlashin, Stanislav
Dyakonov, Pavel
Tarkhov, Mikhail
Dagesyan, Sarkis
Rodionov, Sergey
Shpichka, Anastasia
Kostenko, Mikhail
Konev, Stepan
Sergeichev, Ivan
Timashev, Petr
Akhatov, Iskander
Flexible Polycaprolactone and Polycaprolactone/Graphene Scaffolds for Tissue Engineering
title Flexible Polycaprolactone and Polycaprolactone/Graphene Scaffolds for Tissue Engineering
title_full Flexible Polycaprolactone and Polycaprolactone/Graphene Scaffolds for Tissue Engineering
title_fullStr Flexible Polycaprolactone and Polycaprolactone/Graphene Scaffolds for Tissue Engineering
title_full_unstemmed Flexible Polycaprolactone and Polycaprolactone/Graphene Scaffolds for Tissue Engineering
title_short Flexible Polycaprolactone and Polycaprolactone/Graphene Scaffolds for Tissue Engineering
title_sort flexible polycaprolactone and polycaprolactone/graphene scaffolds for tissue engineering
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766362/
https://www.ncbi.nlm.nih.gov/pubmed/31527398
http://dx.doi.org/10.3390/ma12182991
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